A Brief Introduction To Rheumatoid Arthritis
By George Harper
This is according to the National Institute of and Musculoskeletal and Skin Diseases.

You might not know it, but you could be suffering from rheumatoid arthritis. Although rheumatoid is commonly associated with the older generation (people over the age of 65), the disease is found in younger generations - even including children. How could you tell if you have it? Well if you're experiencing morning stiffness for no apparent reason (like if you had done a lot of strenuous exercise the night before, for example), you might be suffering from one of it's symptoms. As mild as you might think morning stiffness is, you really ought to give it some serious thought and consult with your doctor because if that morning stiffness is related to rheumatoid arthritis, you can work to prevent it from disabling or crippling you later on down the road to a point where you can barely function. But rheumatoid isn't just a physical condition. It has the propensity to tax your mental and emotional state of well-being tpp.

This is because can change the way you work, the way you interact with your family, and the way you entertain yourself with recreational activities. You might even know someone with rheumatoid and have observed how this disease changed not only his or her mobility, but also his or her outlook on life. Those of us without rheumatoid tend to take our ability to move anyway we want for granted, but when that ability slowly disappears right before our eyes, it's no surprise that we get depressed about it.

But it doesn't necessary have to be that way. With proper medications, education, support, and prescribed exercises, you could work to prevent the most severe forms of the disease - or at least prolong the worst case symptoms.

Arthritis works in two ways. First, it inflames the muscles, ligaments, and cartilage that sit in-between joints. And it's this inflammation that causes the pain,

Incidence and risk factors of falling in ambulatory patients with rheumatoid arthritis: a prospective 1-year study. - Hayashibara M, Hagino H, Katagiri H, Okano T, Okada J, Teshima R.
A prospective 1-year study showed that fall incidence was 50% in women with rheumatoid arthritis. Multivariate analysis identified swollen joint count, use of antihypertensives or diuretics, one-leg standing time, and sway area measured by stabilometer ... (Source: SafetyLit: All (Unduplicated))<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Molecular Therapies for Systemic Lupus Erythematosus: Clinical Trials and Future Prospects
Exploring new pharmacological options and therapeutic avenues for lupus: a focus on non-antibody molecular strategies. Arthritis Research & Therapy (Source: Medscape Today Headlines)
Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression
Conclusions: These results suggest that abnormal production of leptin by OA Ob could be responsible, in part, for the elevated levels of ALP, OC, collagen type 1 and TGF-beta1 observed in these cells compared to normal. Leptin also stimulated cell proliferation, and Erk 1/2 and p38 signaling. Taken together, these data suggest leptin could contribute to abnormal osteoblast function in OA. (Source: Arthritis Research and Therapy)
Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk of bias assessment
A food supplement containing fish oils, urtica dioica, Zinc, and Vitamin E (Phytalgic(R)) for osteoarthritis (OA) has now been tested in a placebo-controlled trial for three months and according to the authors has a very large clinical effect, considerably larger than any other known product. Even experts endorsing nutraceuticals for OA symptoms would probably agree that a nutraceutical with an effect size above .5 is rarely seen. Despite our concern about the trial registration taking place after the study was completed, and the likelihood that patients would note the taste of fish, thus leading to detection bias, we consider these data promising although with a high risk of bias. (Source: Arthritis Research and Therapy)
Identification of a Novel Candidate Locus for Juvenile Idiopathic Arthritis at 14q13.2 in the Latvian Population by Association Analysis with Microsatellite Markers
DNA and Cell Biology , Vol. 0, No. 0. (Source: DNA and Cell Biology)
Cystatin C is a sensitive marker for detecting a reduced glomerular filtration rate when assessing chronic kidney disease in patients with rheumatoid arthritis and secondary amyloidosis.
Conclusions: Serum cysC can identify a reduced GFR more accurately than sCr-eGFRs. Serum cysC &gt;1.09 mg/L (i.e. eGFR(Rule)&lt;60 mL/min/1.73 m(2)) could be a marker of a reduced GFR, and serum cysC &gt;1.365 mg/L would strongly suggest a reduced GFR in patients who have RA with secondary amyloidosis. PMID: 20132068 [PubMed - in process] (Source: Scandinavian Journal of Rheumatology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Expression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis.
Conclusion: The present study demonstrated that T helper cells from RA patients display a significantly altered expression profile of Notch receptors and enhanced activation of Notch signalling compared with HC. PMID: 20132067 [PubMed - in process] (Source: Scandinavian Journal of Rheumatology)
Time to methotrexate treatment in patients with rheumatoid arthritis referred to hospital.
Conclusions: The data suggest that reduction in the time to start MTX treatment after referral to hospital could be improved, especially among patients with less severe symptoms. However, our results show that treatment practice in recent years has changed towards an earlier MTX treatment start. PMID: 20132066 [PubMed - in process] (Source: Scandinavian Journal of Rheumatology)
Can disease-modifying anti-rheumatic drugs be discontinued in long-standing rheumatoid arthritis? A 15-year follow-up.
Conclusions: Our results indicate that most of the patients with long-standing RA require continuous DMARD treatment. If the treatment is discontinued, patients should be followed-up closely and DMARDs readministered without delay if the disease flares up. PMID: 20132065 [PubMed - in process] (Source: Scandinavian Journal of Rheumatology)
A case of gouty arthritis following percutaneous radiofrequency ablation for hepatocellular carcinoma.
We describe a case of acute gouty arthritis in a 71-year-old man with chronic renal failure who was treated with RFA for a HCC lesion and who had hepatitis B-associated cirrhosis and mild renal insufficiency. Regular surveillance of the patient detected a 3.5 cm HCC lesion. Because the patient had declined surgery, RFA was chosen for therapy. On the third post-procedural day, the laboratory results showed increases in his uric acid and potassium levels, which were compatible with a tumor lysis syndrome. On the 6th post-procedural day, the patient complained of new right knee pain. Subsequent joint aspiration revealed monosodium urate monohydrate crystals. We made the diagnosis of acute gouty arthritis arising from tumor lysis and liver infarction caused by HCC ablation, which was aggravate...
FDA approves tocilizumab to treat rheumatoid arthritis.
Authors: Thompson CA PMID: 20133526 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Older Women with Gout at Risk of MI (CME/CE)
Elderly women with gout are at increased risk of acute myocardial infarction, even more so than men with this painful arthritis, a population-based study found. (Source: MedPage Today Cardiovascular)
Weak associations between human leucocyte antigen genotype and acute myocardial infarction
Conclusions. This study demonstrates that the associations between HLA-DRB1 and DQA1 loci and cardiovascular disease exists but that they are considerably weaker than those previously reported for other diseases with an established autoimmune aetiology such as type 1 diabetes, systemic lupus erythematosus and rheumatoid arthritis. (Source: Journal of Internal Medicine)
Glioblastoma Invasion, Cathepsin B, and the Potential for Both to be Inhibited by Auranofin, an Old Anti-Rheumatoid Arthritis Drug
Cen Eur NeurosurgDOI: 10.1055/s-0029-1242756© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Zentralblatt fur Neurochirurgie - Central European Neurosurgery)
Exploring the Link Between Anti-TNF-alpha Therapy in RA and Cancer
Is anti-TNF-alpha therapy in rheumatoid arthritis associated with increased risk for cancer? A large-scale longitudinal Swedish registry study says no. Medscape Rheumatology (Source: Medscape Today Headlines)
Response to Rituximab and Timeframe to Relapse in Rheumatoid Arthritis Patients: Association with B-Cell Markers
(Source: Molecular Diagnosis)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
From pond scum to pharmacy shelf
Nature Medicine 16, 146 (2010). doi:10.1038/nm0210-146 Author: Amber Dance Protein-based therapies promise to treat everything from cancer to arthritis, but the bacteria and mammalian cells that usually produce proteins leave much to be desired. New research shows that green algae&#8212;and genetically tweaked yeast&#8212;can churn out proteins that are cheaper and better tailored for human use than those made by traditional systems. Amber Dance reports on these new recruits in the pharma factory. (Source: Nature Medicine)
The Biological and Clinical Importance of the 'New Generation' Cytokines in Rheumatic Diseases
What role do cytokines play in the pathophysiology of arthritis and other inflammatory diseases? Arthritis Research & Therapy (Source: Medscape Rheumatology Headlines)
Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis
Pharmacogenomics , February 2010, Vol. 11, No. 2, Pages 163-175. (Source: Future Medicine: Pharmacogenomics)
Tailor Etanercept to Symptoms in Psoriasis and Psoriatic Arthritis (CME/CE)
The decision to use once-weekly or twice-weekly etanercept in patients with both psoriasis and psoriatic arthritis should be determined by the cutaneous and joint symptoms of the patient, researchers said. (Source: MedPage Today Dermatology)
HSS Supports Arthritis Foundation Focus On Raising National Awareness Of Osteoarthritis
Hospital for Special Surgery, (HSS), a world leader in orthopedics and rheumatology, announced its support of the Arthritis Foundation and Ad Council newly launched campaign, "Moving is the Best Medicine," to raise awareness of osteoarthritis, increase public health education and support breakthrough research. "Like the Arthritis Foundation, we are focusing our extensive clinical and research resources on raising awareness of the potentially debilitating effects of osteoarthritis in this country," said Stephen Paget, M.D., physician-in-chief and chair of the division of rheumatology at HSS... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
HSS Supports Arthritis Foundation Focus On Raising National Awareness Of Osteoarthritis
Hospital for Special Surgery, (HSS), a world leader in orthopedics and rheumatology, announced its support of the Arthritis Foundation and Ad Council newly launched campaign, "Moving is the Best Medicine," to raise awareness of osteoarthritis, increase public health education and support breakthrough research... (Source: Bones / Orthopaedics News From Medical News Today)
Designing Easy-To-Use Products With The Help Of Arthritis Simulation Gloves
As the U.S. population ages, manufacturers of consumer goods are realizing that many customers may not be as nimble-fingered or sharp-sighted as they once were. To help product designers and engineers address those changing requirements, researchers at the Georgia Tech Research Institute (GTRI) have been developing evaluation methods and design techniques to identify and address the needs of all consumers, including those with functional limitations... (Source: Health News from Medical News Today)
Designing Easy-To-Use Products With The Help Of Arthritis Simulation Gloves
As the U.S. population ages, manufacturers of consumer goods are realizing that many customers may not be as nimble-fingered or sharp-sighted as they once were... (Source: Seniors / Aging News From Medical News Today)
Anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis
Conclusion&nbsp;&nbsp;Anti-CCP antibodies could be detected more frequently in the sera of JIA patients with severe manifestations like-erosions and deformity. It was also more significantly associated with seropositive polyarticular JIA than other types. It can be presumed from these results that anti-CCP antibodies can be used as a marker to predict severe course of JIA at the onset to guide optimal aggressive therapy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12098-010-0006-4Authors R. Gupta, Clinical Immunology and Rheumatology Services New Delhi IndiaM. M. Thabah, Clinical Immunology and Rheumatology Services New Delhi IndiaB. Vaidya, Clinical Immunology and Rheumatology Services New Delhi IndiaS. Gupta, Maulana Azad Institute of Dental Sciences Dep...
Dry Skin
Title: Dry SkinCategory: Diseases and ConditionsCreated: 2/5/2010 5:21:00 PMLast Editorial Review: 2/5/2010 5:21:00 PM (Source: MedicineNet Arthritis General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Nanofiber Gel May Spur Growth of New Knee Cartilage
Title: Nanofiber Gel May Spur Growth of New Knee CartilageCategory: Health NewsCreated: 2/4/2010 4:10:00 PMLast Editorial Review: 2/5/2010 (Source: MedicineNet Arthritis General)
A Variant of TNFR2-Fc Fusion Protein Exhibits Improved Efficacy in Treating Experimental Rheumatoid Arthritis
Author Summary Rheumatoid arthritis (RA) is a frequently occurring, chronic, debilitating disease. TNF? plays a pivotal role in regulating its inflammatory response. TNF? inhibition with TNF receptor 2-Fc fusion protein (TNFR2-Fc) was effective in the treatment of RA. However, quite a few patients may not achieve good clinical outcomes after TNFR2-Fc therapy, and the high dosage of TNFR2-Fc in clinical treatment usually causes some side effects, such as injection site reactions. Enhancing the affinity of TNFR2-Fc to TNF? would be of benefit to its therapeutic effect on RA, and may reduce the clinical dosage. We modeled the interactions of TNF? and TNFR2, and figured out the sites that may be critical for ligand-receptor binding. A high affinity TNFR2-Fc variant (E92N/W89Y) was obtaine...
Surveillance of certain health behaviors and conditions among States and selected local areas --- behavioral risk factor surveillance system, United States, 2007.
This report presents results for 2007 for all 50 states, the District of Columbia, the Commonwealth of Puerto Rico, Guam, the Virgin Islands, 184 metropolitan and micropolitan statistical areas (MMSAs), and 298 counties. Results: In 2007, prevalence estimates of risk behaviors, chronic conditions, and the use of preventive services varied substantially by state and territory, MMSA, and county. The following is a summary of results listed by BRFSS question topic. Each set of proportions refers to the range of estimated prevalence for the disease, condition, or behavior, as reported by the survey subject. Adults who reported fair or poor health: 11% to 32% for states and territories and 6% to 31% for MMSAs and counties. Adults with health-care coverage: 71% to 94% for states and territories ...
Exercise programme linked to denser bones in older women
An 18-month exercise programme with a special focus on intensity could help to improve bone density and reduce the risk of fractures in older women, new research suggests. (Source: Arthritis Research Campaign)
'Smart coating' may improve hip and knee implants
Scientists have developed a 'smart coating' that may help surgical implants - such as those used to replace damaged hip and knee joints - to bond with a patient's bone. (Source: Arthritis Research Campaign)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Does Gastrointestinal Adverse Drug Reaction Influence Therapeutic Effect in the Treatment of Rheumatoid Arthritis?
The Journal of Alternative and Complementary Medicine , Vol. 0, No. 0. (Source: The Journal of Alternative and Complementary Medicine)
Performance analysis of the ARCHITECT anti-cyclic citrullinated peptide antibody in the diagnosis of rheumatoid arthritis
Clinical Chemistry and Laboratory Medicine 48 (2): 225-230 Abstract Background: Anti-cyclic citrullinated peptide (CCP) antibody is emerging as an important diagnostic marker for rheumatoid arthritis (RA). We evaluated the analytical and diagnostic performance of the ARCHITECT anti-CCP (Abbott Diagnostics), a new fully automated chemiluminescent microparticle immunoassay. Methods: Serum samples from 69 patients with RA and 86 non-RA patients were used to evaluate the performance of the ARCHITECT anti-CCP assay, and the results were compared with those of EliA CCP (Phadia). The optimal cut-off value was calculated using receiver operating characteristic (ROC) curve analysis. Results: Within-run and total imprecision (%CV) of the ARCHITECT anti-CCP were (Source: Clinical Chemistry and Labora...
Arthritis Foundation Awareness to Reduce Osteoarthritis
The Centers for Disease Control and Prevention (CDC) and the Arthritis Foundation today announced a major initiative to dramatically reduce the impact of osteoarthritis on Americans. (Source: Disabled World)
Can Blood Samples Predict Arthritic Rheumatism?
Levels of inflammatory proteins, so-called cytokines, are elevated in the blood even before the onset of arthritic rheumatism. This means that such blood samples could be used to predict the development of the disease and thereby make it possible to prevent the pathological process, according to an article by Umea researcher Solbritt Rantapaa Dahlqvist and her associates in the journal Arthritis and Rheumatism. The research team analyzed blood samples from 86 individuals who donated samples to the Medical Biobank before they developed arthritic rheumatism... (Source: Health News from Medical News Today)
Can Blood Samples Predict Arthritic Rheumatism?
Levels of inflammatory proteins, so-called cytokines, are elevated in the blood even before the onset of arthritic rheumatism... (Source: Arthritis News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Kidney Function May Be Tied to Bone Loss
Title: Kidney Function May Be Tied to Bone LossCategory: Health NewsCreated: 2/3/2010 4:10:00 PMLast Editorial Review: 2/4/2010 (Source: MedicineNet Arthritis General)
Potential Use of Plectranthus amboinicus in the Treatment of Rheumatoid Arthritis
Plectranthus amboinicus (P. amboinicus) is a folk herb that is used to treat inflammatory diseases or swelling symptoms in Taiwan. We investigated therapeutic efficacy of P. amboinicus in treating Rheumatoid Arthritis (RA) using collagen-induced arthritis animal model. Arthritis was induced in Lewis rats by immunization with bovine type II collagen. Serum anti-collagen IgG, IgM and C-reactive protein (CRP) were analyzed. To understand the inflammation condition of treated animals, production of TNF-, IL-6 and IL-1&beta; from peritoneal exudates cells (PEC) were also analyzed. P. amboinicus significantly inhibited the footpad swelling and arthritic symptoms in collagen-induced arthritic rats, while the serum anti-collagen IgM and CRP levels were consistently decreased. The production of pro...
Physical Activity Associated With Healthier Aging
Physical activity appears to be associated with a reduced risk or slower progression of several age-related conditions as well as improvements in overall health in older age, according to a commentary and four articles published in the January 25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. Exercise has previously been linked to beneficial effects on arthritis, falls and fractures, heart disease, lung disease, cancer, diabetes and obesity, write Jeff Williamson, M.D., M.H.S., and Marco Pahor, M.D., of University of Florida, Gainesville, in a commentary... (Source: Health News from Medical News Today)
Long term safety of rituximab in rheumatoid arthritis
Source: J Rheumatol Area: News The findings of a pooled analysis of long term safety data from patients with rheumatoid arthritis (RA) treated with rituximab in combination with methotrexate in a global clinical trial programme have been published in the Journal of Rheumatology. &nbsp; The analysis involved 2578 patients who received at least 1 course of rituximab and were based on 5013 patient-years of rituximab exposure. This found the following: &nbsp; .&nbsp;The most frequent adverse event (AE) was infusion-related reactions (25% of patients during the first infusion of course 1). &nbsp; .&nbsp;Less than 1% of infusion-related reactions were considered serious. &nbsp; .&nbsp;Rates of AE (359.6 events per 100 pt-yrs) and serious AE (SAE; 17.85 events/100 patient-yrs) we...
Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data
Conclusions: Traditional and selective COX-2 NSAIDs were perceived as safe by pediatric specialists. The data were compared to the published pediatric safety literature. (Source: Pediatric Rheumatology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Case report: Hip septic arthritis and abcess after diagnostic coronary angiography.
Authors: Ayhan H, Akar Bayram N, Keles T, Durmaz T, Bozkurt E Coronary angiography is an invasive procedure which can have some complications. Septic arthritis and abscess after coronary angiography are extremely rare. In this case, a 49-year-old-man presented to our hospital with non-ST-segment elevation myocardial infarction. After coronary angiography, he had right leg weakness, femoral palsy, inguinal pain, but there was no bleeding or hematoma. The cause was right hip septic arthritis and abscess. PMID: 20133339 [PubMed - as supplied by publisher] (Source: Perfusion)
Efficacy and Safety of Ketoprofen Patch in Patients With Rheumatoid Arthritis: A Randomized, Double-Blind, Placebo-Controlled Study.
This study assessed the efficacy and safety of ketoprofen patch compared with placebo in patients who had rheumatoid arthritis and persistent wrist pain. Patients (N = 676) who had achieved systemic disease control with a disease-modifying antirheumatic drug and/or systemic corticosteroid, but still had persistent wrist pain, were randomized to a 2-week course of once-daily treatment with application of a 20-mg ketoprofen patch or a placebo patch to the wrist. The primary efficacy end point was the percent change from baseline to the end of treatment in the intensity of wrist pain scored by each patient on a 100-mm visual analog scale. The mean +/- SD percent change on the pain intensity scale was significantly larger in patients treated with ketoprofen than in those receiving placebo (31....
Arthritis Research Campaign chosen as Charity of the Year by the National Gardens Scheme
The National Gardens Scheme (NGS) has chosen the Arthritis Research Campaign as its Charity of the Year for 2010. (Source: Arthritis Research Campaign)
When Immune-Neuro-Endocrine Interactions Are Disrupted: Experimentally Induced Arthritis as an Example
Neuroimmunomodulation 2010;17:165–168 (DOI:10.1159/000258714) (Source: Neuroimmunomodulation)
Contralateral electroacupuncture pretreatment suppresses carrageenan-induced inflammatory pain via the opioid-mu receptor
Abstract&nbsp;&nbsp;Acupuncture has been used to treat various clinical diseases in Eastern medicine. To investigate the analgesic effect of electroacupuncture (EA) pretreatment on carrageenan-induced inflammatory pain, we studied on the effect of EA parameters on an animal model of acute arthritic pain. Pretreatment with 1&nbsp;mA, 10&nbsp;Hz EA prior to carrageenan injection under halothane anesthesia suppressed carrageenan-induced pain. Interestingly, EA stimulation of the ?Zu-San-Li? (ST36) acupuncture point (1&nbsp;mA, 10&nbsp;Hz) contralateral to the site of the carrageenan injection in the rat synovial cavity produced significantly greater improvement of the weight-bearing force compared with EA stimulation of the ?San-Yin-Jiao? acupuncture point. To determine how ST36 ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Seasoned Pharmaceutical CEO Returns To PreEmptive Meds, Inc.
Along with Dr. Joe Fenn, Mr. Blitzer co-founded PreEmptive Meds, Inc. (PMI) and served as Chief Executive Officer from late 2006 until June 2008. The company has pioneered the promotion of branded, proprietary, all natural, nutraceutical formulations directly to Primary Care Physicians for various pre-disease conditions such as diabetes (PreCrea&#174;), elevated cholesterol and lipids (PreLipid&#174; and PreLipid&#174; Plus), symptoms associated with perimenopause (PreMenora&#174; and PreMenora&#174; Plus), and arthritis symptoms of joint pain and inflammation (PreArthros&#174; and Pre Arthros&#174; Plus). Physician promotion is conducted directly to Primary Care Physicians with a pharmaceutical based sales force comprising seasoned sales associates familiar with the Primary Care Physician...
Rehabilitation Research and Training Centers (RRTCs)--Enhancing the Health and Wellness of Individuals With Arthritis CFDA 84.133B-7
Funding Opportunity Number: ED-GRANTS-020210-001 Opportunity Category: DiscretionaryFunding Instrument Type: GrantCategory of Funding Activity: EducationCFDA Number: 84.133Eligible Applicants State governmentsCounty governmentsCity or township governmentsSpecial district governmentsIndependent school districtsPublic and State controlled institutions of higher educationNative American tribal governments (Federally recognized)Public housing authorities/Indian housing authoritiesNative American tribal organizations (other than Federally recognized tribal governments)Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationPrivate institutions o...
Free radical scavenging activity of &lt;i&gt;Calotropis&lt;/i&gt; &lt;i&gt;gigantea&lt;/i&gt; on streptozotocin-induced diabetic rats
Rathod N R, Raghuveer I, Chitme H R, Chandra RIndian Journal of Pharmaceutical Sciences 2009 71(6):615-621&#x0026;lt;i&#x0026;gt;Swarnabhasma&#x0026;lt;/i&#x0026;gt; , an Ayurvedic preparation containing &#x0026;lt;i&#x0026;gt;Calotropis gigantea&#x0026;lt;/i&#x0026;gt; R. Br. (Asclepiadaceae) is extensively used by Ayurvedic physicians for treatment of diabetes mellitus, bronchial asthma, rheumatoid arthritis and nervous disorders. In the present study, we report the effect of chloroform extracts of &#x0026;lt;i&#x0026;gt;Calotropis gigantea&#x0026;lt;/i&#x0026;gt; leaf and flower on free radical scavenging activity, and lipid profile in streptozotozin-induced diabetic rats. The lipid peroxidation, superoxide dismutase, and catalase were measured in liver homogenate and serum glutamic pyr...
What Epidemiology Has Told Us About Risk Factors and Aetiopathogenesis in Rheumatic Diseases
Have epidemiological studies provided good markers for assessing the risk of developing arthritis and gout? Arthritis Research & Therapy (Source: Medscape Today Headlines)
FDA Approves Xiaflex For Debilitating Hand Condition
The U.S. Food and Drug Administration approved Xiaflex (collagenase clostridium histolyticum) as the first drug to treat a progressive hand disease known as Dupuytren's contracture, which can affect a person's ability to straighten and properly use their fingers. Dupuytren's contracture affects the connective tissue found beneath the skin in the palm of the hand. Too much collagen can build up, forming thick, rope-like cords of tissue that can prevent the fingers from being able to relax and straighten normally. The disorder is most common in Caucasians and in men over age 50... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
FDA Approves Xiaflex For Debilitating Hand Condition
The U.S. Food and Drug Administration approved Xiaflex (collagenase clostridium histolyticum) as the first drug to treat a progressive hand disease known as Dupuytren's contracture, which can affect a person's ability to straighten and properly use their fingers. Dupuytren's contracture affects the connective tissue found beneath the skin in the palm of the hand... (Source: Arthritis News From Medical News Today)
Optimal care for rheumatoid arthritis: a focus group study
Abstract&nbsp;&nbsp;Our study sought to identify barriers to optimal care for individuals with rheumatoid arthritis (RA). Our study was set in a population with universal access to comprehensive health care in the context of a university hospital health network. Using purposive sampling, we invited RA patients, health professionals, and decision makers from urban and rural regions to participate in structured focus group interviews. Content analysis was performed to determine themes emerging from the data. We identified four general themes. First, initial barriers to optimal care for people begin before primary care contact, at the level of the general population and/or related to primary care access. Second, many factors (at the patient, physician, and system level) influenced how q...
Etanercept related pseudo-empyema in rheumatoid arthritis
Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10067-009-1360-3Authors Doron Rimar, Bnai Zion Medical Center Department of Rheumatology POB 4940 Haifa 31048 IsraelMichael Rozenbaum, Bnai Zion Medical Center Department of Rheumatology POB 4940 Haifa 31048 IsraelGleb Slobodin, Bnai Zion Medical Center Internal medicine POB 4940 Haifa 31048 IsraelNina Boulman, Bnai Zion Medical Center Department of Rheumatology POB 4940 Haifa 31048 IsraelItzhak Rosner, Bnai Zion Medical Center Department of Rheumatology POB 4940 Haifa 31048 Israel Journal Clinical RheumatologyOnline ISSN 1434-9949Print ISSN 0770-3198 (Source: Clinical Rheumatology)
Arthritis simulation gloves aid companies in designing easy-to-use products
(Georgia Institute of Technology Research News) Researchers have designed arthritis simulation gloves that reproduce the reduction in functional capacity experienced by persons with arthritis. The gloves help those responsible for consumer products understand how arthritis affects a person's ability to grasp, pinch, turn, lift and twist objects. (Source: EurekAlert! - Social and Behavioral Science)
Comparison of two etanercept regimens for treatment of psoriasis and psoriatic arthritis: PRESTA randomised double blind multicentre trial
Objectives To compare the efficacy over 12 weeks of two different etanercept regimens in treating the skin manifestations of psoriasis in patients who also have psoriatic arthritis and to evaluate... (Source: BMJ Online First)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Etanercept for psoriatic arthritis
(Source: BMJ Online First)
Comorbidities associated with psoriasis: An experience from the Middle East
Recent studies suggest that psoriasis patients have higher rates of comorbidities. We sought to determine the prevalence of comorbidities and co-medications in our psoriasis patients. We conducted case-control study in 1835 patients with psoriasis vulgaris and age- and gender-matched cohort without psoriasis. Patients were examined for clinical characteristics of psoriasis, PASI scores, and data of age, sex, body mass index (BMI), smoking status, comorbidities, and co-medications were analysed for both patients and controls. We identified 1661 (92.8%) patients with mild to moderate psoriasis (PASI < 10) and 129 patient's (7.03%) with severe psoriasis (PASI > 10). Patients with psoriasis were more likely to be current smokers (51.34% vs 32.51% controls). Respective prevalence rates of risk ...
Correct dose of etanercept for psoriatic arthritis 'depends on the individual'
A comparison of two doses of the drug etanercept for people with psoriatic arthritis has concluded that either may be appropriate, depending on an individual's symptoms. (Source: Arthritis Research Campaign)
Study Assesses Computer Use in Individuals With RA
Many people with rheumatoid arthritis can type on a computer as quickly as someone without the condition, but their use of a mouse may be slower, according to research published in the February issue of Arthritis Care &amp; Research. (Source: Modern Medicine)
Back Pain and Total Hip Arthroplasty: A Prospective Natural History Study.
CONCLUSIONS: Hip and spine arthritis often coexist. Most patients who presented with hip arthritis and lower lumbar pain experienced resolution or improvement of their pain after THA. LEVEL OF EVIDENCE: Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence. PMID: 20127429 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Hand and wrist arthritis of Behçet disease: Imaging features.
Conclusion: Imaging manifestations of arthritis of Beh&#xE7;et disease vary, and may be similar to other seronegative arthritides. PMID: 20121672 [PubMed - as supplied by publisher] (Source: Acta Radiologica)
HIV therapeutic possibilities of gold compounds.
Authors: Fonteh PN, Keter FK, Meyer D Highly active antiretroviral therapy (HAART) has resulted in decreased mortality and morbidity from the acquired immune deficiency syndrome caused by the human immunodeficiency virus (HIV). Drug resistance and toxicity of HAART has led to the search for novel inhibitors of HIV infection. Gold-based compounds have shown promising activity against a wide range of clinical conditions and microorganism infections including HIV-1. A typical example is auranofin which resulted in an elevated CD4+ T-cell count in an HIV patient being treated for psoriatic arthritis. In addition, reports exist on gold-based inhibitors of reverse transcriptase (RT), protease (PR) and viral entry of host cells. These and other characteristics of gold-based HIV drugs are revi...
Rituximab Safe Long-Term in RA (CME/CE)
Multiple courses of rituximab were safe for patients with advanced rheumatoid arthritis, with no increase in serious adverse events or serious infections, an analysis of data from an international follow-up program demonstrated. (Source: MedPage Today Geriatrics)
Arthritis Genes Discovered By University Of Queensland Scientists, Australia
University of Queensland researchers have been part of a major breakthrough in understanding the cause of the debilitating arthritic condition ankylosing spondylitis (AS)... (Source: Arthritis News From Medical News Today)
Arthritis Genes Discovered By University Of Queensland Scientists, Australia
University of Queensland researchers have been part of a major breakthrough in understanding the cause of the debilitating arthritic condition ankylosing spondylitis (AS). The research, led by Professor Matt Brown from UQ's Diamantina Institute for Cancer Immunology and Metabolic Medicine, has identified susceptibility genes for AS, which is a type of inflammatory arthritis that targets the joints of the spine... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Biomarker could help doctors tailor treatment for rheumatoid arthritis
Investigators have identified a biomarker that could help doctors select patients with rheumatoid arthritis who will benefit from therapy with drugs such as Enbrel, a tumor necrosis factor-antagonist drug. (Source: ScienceDaily Headlines)
Fewer Childhood Deaths From Rheumatic Disease
Title: Fewer Childhood Deaths From Rheumatic DiseaseCategory: Health NewsCreated: 2/1/2010 12:10:00 PMLast Editorial Review: 2/2/2010 (Source: MedicineNet Arthritis General)
Whiplash-associated disorders: who gets depressed? Who stays depressed?
Abstract&nbsp;&nbsp;Depression is common in whiplash-associated disorders (WAD). Our objectives were to identify factors associated with depressive symptomatology occurring in the initial stages of WAD, and to identify factors predicting the course of depressive symptoms. A population-based cohort of adults sustaining traffic-related WAD was followed at 6&nbsp;weeks, 3, 6, 9, and 12&nbsp;months. Baseline measures (assessed a median of 11&nbsp;days post-crash) included demographic and collision-related factors, prior health, and initial post-crash pain and symptoms. Depressive symptomatology was assessed at baseline and at each follow-up using the Centre for Epidemiological Studies Depression Scale (CES-D). We included only those who participated at all follow-ups (n&nbsp;=&nbsp;3,452;...
Midterm Outcomes After Meniscal Allograft Transplantation: Comparison of Cases With Extrusion Versus Without Extrusion
Conclusion Joint space width was slightly narrower after MAT. Extrusion had no effect on 5-year clinical or radiological outcomes. (Source: The American Journal of Sports Medicine)
'Immune jab' blocks chronic pain
A treatment already used for immune diseases like rheumatoid arthritis appears to also work for chronic pain, scientists discover. (Source: BBC News | Health | UK Edition)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)
Conclusions and implications: ATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity. (Source: British Journal of Pharmacology)
Suppression of LPS-induced inflammatory responses in macrophages infected with Leishmania
Conclusions: During uptake by macrophages, Leishmania evades the activation of a broad range of cytokines and chemokines. Further, in the presence of a strong inflammatory stimulus, Leishmania suppresses certain proinflammatory cytokine responses in a parasite-specific manner, however it augments the production of other proinflammatory cytokines. Our findings highlight the complexity of inflammatory cytokine signalling regulation in the context of the macrophage and Leishmania interaction and confirm the utility of the Leishmania/ macrophage infection model as an experimental system for further studies of inflammatory regulation. Such studies may advance the development of therapies against inflammatory disease. (Source: Journal of Inflammation)
Effect of cyclosporine on blood pressure
Source: Cochrane Library Area: Evidence > Medication Safety Abstract &nbsp; Background Cyclosporine is an immunosuppressive agent used for different autoimmune diseases. The official Canadian indications for cyclosporine are solid organ transplantation, bone marrow transplantation, psoriasis, rheumatoid arthritis and nephritic syndrome (e-CPS 2008). The expanding range of indications for cyclosporine therapy will lead to more patients receiving chronic therapy with possible side effects, hypertension being one of the most common. Therefore it is essential to know the magnitude of increase of blood pressure (BP) associated with cyclosporine in order to appropriately manage patients receiving the drug. &nbsp; Objectives The primary objective of this systematic review is to evaluate ...
Managing non-response to rituximab in rheumatoid arthritis
Source: Arthr Rheum Area: News A brief report published early online in Arthritis and Rheumatism describes factors predicting non-response to rituximab in patients with rheumatoid arthritis (RA), and the response to re-treatment in these patients. &nbsp; The authors describe outcomes from a series of 158 patients. Highly sensitive flow cytometry (HSFC) was used to determine persistent circulating B cells at week 2, as there is evidence that this is associated with lack of response. Complete data were available for 103 patients: 65 who responded to the first cycle of rituximab treatment and 38 who did not. Of the non-responders, 25 received a second treatment cycle at least 6 months after the first. &nbsp; In the analyses, complete B-cell depletion measured by HSFC predicted a resp...
NICE guidance on osteoporosis prevention 'will remain unchanged'
The National Institute for Health and Clinical Excellence (NICE) has confirmed that its guidance on the prevention of osteoporotic fractures will not be changed. (Source: Arthritis Research Campaign)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
UK scientists discover new treatment for rare pain syndrome
Patients with a rare but extreme pain syndrome may benefit from a treatment that dampens inflammation, UK scientists have found. (Source: Arthritis Research Campaign)
Competitive sports place teens at risk of low back pain
Teenagers who have played competitive sports since childhood may face a heightened risk of low back pain, new research suggests. (Source: Arthritis Research Campaign)
Hsp40 proteins modulate humoral and cellular immune response in rheumatoid arthritis patients.
Authors: Tukaj S, Kotlarz A, Jozwik A, Smolenska Z, Bryl E, Witkowski JM, Lipinska B Recent research on the heat shock proteins (Hsps) in chronic inflammatory diseases indicates that Hsps may have disease-suppressive activities. Our aim was to characterize immune response directed to bacterial (DnaJ) and human Hsp40s in patients with rheumatoid arthritis (RA). We found elevated levels of anti-DnaJ, anti-Hdj2, and anti-Hdj3 (but not ant-Hdj1) serum antibodies in the RA patients (P &lt;/= 0.001) compared to healthy controls. In peripheral blood mononuclear cells (PBMCs) culture, all tested Hsp40 proteins significantly inhibited the divisions of CD4+ and CD8+ T cells of the RA patients but not those of the controls. Both DnaJ and Hdj2 stimulated secretion of the main anti-inflammatory cyt...
Fish Oil to Prevent Psychotic Disorders?
As reported by the Associated Press, this month the Archives of General Psychiatry has published the results of a study that was designed to find out whether omega-3 fatty acids such as are found in fish oil have any benefit in preventing psychosis from developing, specific in teens and young adults. The study was small - just 81 participants - but the results were strong enough to make the outcome very encouraging. The patients, aged 13 to 25, were selected on the basis of being at ultra-high risk for developing a psychotic disorder such as schizophrenia, based on early symptoms. After one year, 27.5% of the placebo group had developed full-blown psychosis, but only 4.9% of those taking omega-3 fatty acids had done so. If these findings stand up in larger studies, will the results turn ...
Methicillin-Resistant Staphylococcus aureus as a Cause of Lumbar Facet Joint Septic Arthritis: A Report of Two Cases
(Source: JBJS [Am])<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Postoperative Infection Rates in Foot and Ankle Surgery: A Comparison of Patients with and without Diabetes Mellitus
Conclusions: Patients with diabetes mellitus are at increased risk of severe infection compared with those without diabetes. Patients with uncomplicated diabetes did not have an increased risk of postoperative infection compared with patients without diabetes, whereas patients with complicated diabetes had a significantly higher rate of postoperative infection. Level of Evidence: Prognostic Level II. See Instructions to Authors for a complete description of levels of evidence. (Source: JBJS [Am])
The diagnostic utility of the anti-CCP antibody test is no better than rheumatoid factor in South Africans with early rheumatoid arthritis
Abstract&nbsp;&nbsp;To establish the diagnostic utility of the anti-cyclic-citrullinated peptide antibody (aCCP) test in Black South Africans with early rheumatoid arthritis (RA). A cross-sectional study comparing the rheumatoid factor (RF) and aCCP status in RA patients and a control group consisting of healthy subjects, and patients with systemic lupus erythematosus (SLE) and scleroderma. The sensitivity, specificity, positive (PPV) and negative predictive values of the aCCP test alone were 82.5%, 84.9%, 87.6% and 79% versus 81.7%, 90.7%, 92.5% and 78% for RF alone. The best specificity (95.3) and PPV (95.8%) was observed when both aCCP and RF tests were positive. Patients with erosive disease had a significantly higher mean RF titre compared with those with non-erosive disease (p?.
The Biological and Clinical Importance of the 'New Generation' Cytokines in Rheumatic Diseases
What role do cytokines play in the pathophysiology of arthritis and other inflammatory diseases? Arthritis Research & Therapy (Source: Medscape Today Headlines)
Gout. Imaging of Gout: Findings and Utility
Several imaging techniques can assist with the diagnosis of gout, including MRI and ultrasonography. Arthritis Research & Therapy (Source: Medscape Today Headlines)
New 'suicide' molecule halts rheumatoid arthritis
Scientists have invented a novel way to halt and even reverse rheumatoid arthritis. They have developed an imitation of a suicide molecule that floats undetected into overactive immune cells responsible for the disease. Referred to as Casper the Ghost, the stealthy molecule causes the immune cells to self-destruct. The approach doesn't carry the health risks of current treatments. The new therapy, tested on mice, stopped the disease cold in 75 percent of the animals. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Leflunomide Equal to Methotrexate in Anti-TNF Combo for RA Treatment (CME/CE)
Treatment regimens combining leflunomide (Arava) with an anti-tumor necrosis factor (TNF) agent were as effective in rheumatoid arthritis as regimens combining methotrexate with the biologics, a randomized Italian study found. (Source: MedPage Today Rheumatology)
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus [LETTERS]
Monozygotic (MZ) twins are partially concordant for most complex diseases, including autoimmune disorders. Whereas phenotypic concordance can be used to study heritability, discordance suggests the role of non-genetic factors. In autoimmune diseases, environmentally driven epigenetic changes are thought to contribute to their etiology. Here we report the first high-throughput and candidate sequence analyses of DNA methylation to investigate discordance for autoimmune disease in twins. We used a cohort of MZ twins discordant for three diseases whose clinical signs often overlap: systemic lupus erythematosus (SLE), rheumatoid arthritis, and dermatomyositis. Only MZ twins discordant for SLE featured widespread changes in the DNA methylation status of a significant number of genes. Gene ontolo...
Newer Biological Agents in Rheumatoid Arthritis: Impact on Health-Related Quality of Life and Productivity
(Source: Drugs)
Deal watch: Dipping into Incyte's JAK-pot
Deal watch: Dipping into Incyte's JAK-pot Nature Reviews Drug Discovery 9, 94 (2010). doi:10.1038/nrd3113 Incyte has entered into two large licensing deals for their JAK1/JAK2 inhibitors INCB28050 and INCB18424. In late December 2009, the worldwide rights to INCB28050, which is in mid-stage trials for rheumatoid arthritis, were acquired by Eli Lilly for US&#36;90 million upfront, with up to &#36;665 (Source: Nature Reviews Drug Discovery)
Tailoring treatment for rheumatoid arthritis
Investigators have identified a biomarker that could help doctors select patients with rheumatoid arthritis who will benefit from treatment with drugs such as Enbrel, a tumor necrosis factor (TNF)-antagonist drug. The study, led by scientists at Hospital for Special Surgery in collaboration with rheumatologists at University of Southern California, appears in the recent issue of the journal Arthritis and Rheumatism........ (Source: Medicineworld.org: New Article Alert)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Long Before Symptoms, Blood May Reveal Rheumatoid Arthritis
Testing could lead to earlier detection and treatment, study suggests Source: HealthDay Related MedlinePlus Topics: Laboratory Tests, Rheumatoid Arthritis (Source: MedlinePlus Health News)
Heal yourself in 15 days - You are what you absorb (part three)
This article continues part three of the 15-part article series called Heal Yourself in 15 Days. In part two, we explored your innate healing potential and saw how powerful your self-healing abilities really are (http://www.naturalnews.com/028060_self_healing_immune_system.html). Here in part three, we look at a powerful principle of nutrition: You aren't what you eat; you are what you ABSORB.Many people suffer from poor digestion. In fact, you might say that most people aren't able to absorb the nutrients they swallow, so they remain in a state of nutritional starvation even though they're taking supplements that would otherwise be quite helpful.These people tend to scratch their heads, wondering why all the nutrients they're swallowing aren't having the positive effects they had hoped fo...
Long Before Symptoms, Blood May Reveal Rheumatoid Arthritis
Title: Long Before Symptoms, Blood May Reveal Rheumatoid ArthritisCategory: Health NewsCreated: 2/1/2010 8:10:00 AMLast Editorial Review: 2/1/2010 (Source: MedicineNet Chronic Pain General)
Long Before Symptoms, Blood May Reveal Rheumatoid Arthritis
Title: Long Before Symptoms, Blood May Reveal Rheumatoid ArthritisCategory: Health NewsCreated: 2/1/2010 8:10:00 AMLast Editorial Review: 2/1/2010 (Source: MedicineNet Senior Health General)
Deep Vein Thrombosis (DVT)
Title: Deep Vein Thrombosis (DVT)Category: Diseases and ConditionsCreated: 2/15/2000 10:55:00 PMLast Editorial Review: 2/1/2010 (Source: MedicineNet Arthritis General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
For the Knee, Shoes and Playing Surface Matter
Title: For the Knee, Shoes and Playing Surface MatterCategory: Health NewsCreated: 1/30/2010 8:10:00 AMLast Editorial Review: 2/1/2010 (Source: MedicineNet Arthritis General)
Long Before Symptoms, Blood May Reveal Rheumatoid Arthritis
Title: Long Before Symptoms, Blood May Reveal Rheumatoid ArthritisCategory: Health NewsCreated: 2/1/2010 8:10:00 AMLast Editorial Review: 2/1/2010 (Source: MedicineNet Arthritis General)
Free radical scavenging: a possible mechanism of action for the anti-inflammatory activity of Russelia equisetiformis (Schlect & Chan) (Scrophulariacae)
Abstract&nbsp;&nbsp;The methanol extract of Russelia equisetiformis (MRE), which exhibited significant antiinflammatory activity, was evaluated for the possible mode of action by studying its antioxidant potential in adjuvant- induced arthritic rats. 1, 1 diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect was determined by spectrophotometric method. The enzymatic activity of the superoxide dismutase, glutathione peroxidase, showed a significant increase, while the lipid peroxide content was found to decrease to a large extent in MRE and indomethacin-treated rats. There was also significant and concentration-dependent increase in the percentage inhibition of DPPH, comparable to that of vitamin E and butylated hydroxyanisole (BHA) which are natural and synthetic antioxidants, re...
Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress
Conclusions: Autophagy induction and CHOP under-expression increases cell resistance against ER stress-induced cell death in fibroblasts from rheumatoid arthritis patients. (Source: BioMed Central)
From the item to the outcome: the promising prospects of PROMIS
Evaluation of patient reported outcomes, and in particular physical function, have gained increasing importance in research and therapy of patients with rheumatic diseases. Most instruments that are used for that purpose are rigid and suffer from floor and ceiling effects when used in patients whose physical function differs from the average. A new approach to the assessment of physical function is by computerised adaptive testing (CAT), by which precision and reliability of the measurement can be achieved for most patients, while even requiring less time for the assessment. Well calibrated and tested item and large item data banks are a prerequisite for this purpose, a process which is summarised in the present report by Bruce and colleagues. (Source: Arthritis Research and Therapy)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Man-made molecule may stop rheumatoid arthritis progression
Scientists have developed a molecule that could help to stop rheumatoid arthritis in its tracks. (Source: Arthritis Research Campaign)
Heavy backpacks may cause spinal strain in children
Children who carry heavy backpacks face a heightened risk of spinal strain and back pain, experts have warned. (Source: Arthritis Research Campaign)
Botox Therapy for Ischemic Digits
Conclusion: Botox appears to provide improvement in digital perfusion and pain reduction in patients with Raynaud's syndrome when conservative management fails. Summary: Digital ulceration associated with Raynaud's syndrome is painful, difficult to treat, and frequently results in patient debilitation and chronic depression. Reports by Sycha and Van Beek have indicated potential benefit for patients with ischemic digits with local injection of botulinum toxin (Euro J Clin Invest 2004;34:312-3; Plast Reconstr Surg 2007;119:217-26). This was a retrospective observational study on outcomes of 19 patients with Raynaud's syndrome treated with botulinum toxin. All patients had chronic ischemic hand pain, and vascular studies had ruled out proximal occlusive disease and underlying disorders, inc...
Results from Phase III trial of golimumab in rheumatoid arthritis
Source: Arthr Rheum Area: News The 48-week results from a multicentre Phase III trial evaluating golimumab ± methotrexate (MTX) versus placebo in the treatment of rheumatoid arthritis (RA) have been published early online in Arthritis and Rheumatism.&nbsp; Golimumab, a monoclonal antibody against tumour necrosis factor (TNF), did not meet the primary endpoint of ACR50 response at week 14, but a higher proportion than placebo met these criteria by week 24 (secondary endpoint).&nbsp;&nbsp; &nbsp; The goal of this study was to assess the efficacy and safety of IV golimumab (with and without MTX) in patients with active RA despite concurrent MTX therapy (15-25mg/week for at least 4 weeks).&nbsp; Participants were randomised to infusions of either 2mg/kg or 4mg/kg golimumab (total n=514) ...
Majority of people 'gain weight after a knee replacement'
New research in the journal Osteoarthritis and Cartilage suggests that most patients who undergo knee replacement surgery put on weight during the two years following their operation. (Source: Arthritis Research Campaign)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Study links hip fractures in grandfathers with low bone density in grandsons
Men whose grandfathers sustained a hip fracture appear to be more likely to have low bone density, a new study suggests. (Source: Arthritis Research Campaign)
Protein may predict effectiveness of anti-TNF drugs
Scientists have discovered a protein that may help to identify those patients who will benefit the most from anti-tumour necrosis factor (TNF) therapy. (Source: Arthritis Research Campaign)
New technique may reduce need for hip replacement after injury
A new surgical technique could prevent many young patients from needing a hip replacement after sustaining a serious injury, surgeons have said. (Source: Arthritis Research Campaign)
Delayed-Onset Ulnar Neuropathy at the Wrist Associated With Distal Radioulnar Joint Arthritis After Radius Malunion: Report of Two Cases
Although ulnar neuropathy can occur at the wrist in association with distal radius fractures, few late-onset cases have been reported. The authors describe 2 cases of delayed-onset ulnar neuropathy at the wrist, which developed 12 and 30 years after sustaining a conservatively treated distal radius fracture. During late neurolysis, both patients were found to have a perforation in the volar wrist capsule and synovitis and arthritis in the distal radioulnar joint. (Source: The Journal of Hand Surgery)
Response: Cricoarytenoid arthritis presenting as croup.
Authors: Marks JL, Mukherjee S, Hull RG PMID: 20118331 [PubMed - in process] (Source: J R Soc Med AND (has...)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Outcome for juvenile idiopathic arthritis
Abstract: Juvenile Idiopathic Arthritis (JIA) is a heterogeneous group of chronic inflammatory conditions comprising several disease subtypes with a widely variable clinical course and outcome. An ideal treatment outcome is one where there is lifelong disease remission with no long-term functional or psychological impact. Although not always achieved, over the past decade there has been considerable progress towards this target. The quality of outcome for JIA is dependent on early diagnosis and intensive management to optimise disease control. This review looks at the key aspects of management in JIA that influence prognosis and outcome. (Source: Paediatrics and Child Health)
Transitional care for young people with connective tissue diseases
Abstract: Within rheumatology, much of the literature in transitional care has addressed young people with juvenile idiopathic arthritis with less attention being directed to another significant group, namely those with connective tissue diseases. These young people, although fewer in number, often present complex challenges during adolescence and the period of transition from paediatric to adult-centred services. This paper aims to explore the particular challenges transition presents to these young people and will discuss potential strategies which health professionals can adopt to effectively address their needs. (Source: Paediatrics and Child Health)
Methicillin-Resistant Staphylococcus aureus as a Cause of Lumbar Facet Joint Septic Arthritis: A Report of Two Cases.
Authors: Krishnan V, Amritanand R, Sundararaj GD PMID: 20124076 [PubMed - in process] (Source: The Journal of Bone and Joint Surgery. American volume)
Postoperative Infection Rates in Foot and Ankle Surgery: A Comparison of Patients with and without Diabetes Mellitus.
CONCLUSIONS: Patients with diabetes mellitus are at increased risk of severe infection compared with those without diabetes. Patients with uncomplicated diabetes did not have an increased risk of postoperative infection compared with patients without diabetes, whereas patients with complicated diabetes had a significantly higher rate of postoperative infection. LEVEL OF EVIDENCE: Prognostic Level II. See Instructions to Authors for a complete description of levels of evidence. PMID: 20124054 [PubMed - in process] (Source: The Journal of Bone and Joint Surgery. American volume)
Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays.
Authors: Wright C, Sibani S, Trudgian D, Fischer R, Kessler B, Labaer J, Bowness P Ankylosing Spondylitis (AS) is a common, inflammatory rheumatic disease, which primarily affects the axial skeleton and is associated with sacroiliitis, uveitis and enthesitis. Unlike other autoimmune rheumatic diseases, such as rheumatoid arthritis or systemic lupus erythematosus, autoantibodies have not yet been reported to be a feature of AS. We therefore wished to determine if plasma from patients with AS contained autoantibodies and if so, characterize and quantify this response in comparison to patients with Rheumatoid Arthritis (RA) and healthy controls. Two high-density nucleic acid programmable protein arrays expressing a total of 3498 proteins were screened with plasma from 25 patients with AS,...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Measurement of quality of life and participant experience with the mindfulness-based stress reduction program.
The objective of this study was to collect quality-of-life data from subjects who participated in the first MBSR program offered at Mayo Clinic. The class was taught as a collaborative effort with the University of Minnesota that had an established MBSR program. Sixteen participants completed a validated, 12-question, linear analogue self-assessment instrument, administered at the beginning and end of the program. Comparison of assessment scores using paired t-tests showed statistically significant improvement in overall quality of life (P=0.04), mental well-being (P=0.005), physical well-being (P&lt;0.001), emotional well-being (P&lt;0.001), level of social activity (P=.02), and spiritual well-being (P=0.006). Although positive changes also were observed for frequency of pain, severity of...
KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.
Authors: Montalban AG, Boman E, Chang CD, Ceide SC, Dahl R, Dalesandro D, Delaet NG, Erb E, Ernst J, Gibbs A, Kahl J, Kessler L, Lundstr&#xF6;m J, Miller S, Nakanishi H, Roberts E, Saiah E, Sullivan R, Wang Z, Larson CJ The tumor necrosis factor-alpha (TNF-alpha) cytokine, secreted by activated monocytes/macrophages and T lymphocytes, is implicated in several diseases, including rheumatoid arthritis, chronic obstructive pulmonary disease, inflammatory bowel disease, and osteoporosis. Monocyte/macrophage production of TNF-alpha is largely driven by p38alpha mitogen activated protein kinase (MAP kinase), an intracellular soluble serine-threonine kinase. p38alpha MAP kinase is activated by growth factors, cellular stresses, and cytokines such as TNF-alpha and interleukin-l (IL-I). The pri...
Frequent attendance in primary care: comparison and implications of different definitions.
CONCLUSION: The way frequent attendance is defined is of crucial importance. It is recommended that a more discriminative definition of frequent attendance is used (the top 10%). PMID: 20132693 [PubMed - in process] (Source: The British Journal of General Practice)
Autoimmune rheumatic diseases: an introduction
The outlook for patients with autoimmune rheumatic diseases has improved. The past five years has seen a narrowing of the gap between an ever-expanding laboratory-based and clinical research arena, and the actual delivery of care at the bedside. Our knowledge about pathogenesis of rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, the systemic vasculitides and other immunologically driven rheumatic diseases is being increasingly linked to intelligently designed therapies and diagnostic modalities. There is increasing awareness that, where possible, patients with these rare conditions should be treated in a research-oriented environment, for example, a clinical trial, so that this gap between the patient and laboratory continues to narrow. We are privileged to have lead...
Autoantibodies in the autoimmune rheumatic diseases
Abstract: The detection of autoantibodies to a variety of antigenic targets plays an important role in the diagnosis of autoimmune rheumatic disease. Rheumatoid factor, antinuclear antibodies and antineutrophil cytoplasmic antibodies have been the key in the diagnosis of rheumatoid arthritis (RA), systemic lupus erythematosus and systemic vasculitis for many years. Antibodies against cyclic citrullinated peptides have been shown to be specific for rheumatoid arthritis and may predict the development of erosive disease, and are being increasingly used in the assessment of patients with RA. There is increasing interest in the use of anti-C1q antibodies for the detection and monitoring of lupus nephritis as this assay appears to be more sensitive than anti-DNA antibodies. Antibodies against ?..<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Biomarker Could Help Doctors Tailor Treatment For Rheumatoid Arthritis
Investigators have identified a biomarker that could help doctors select patients with rheumatoid arthritis who will benefit from therapy with drugs such as Enbrel, a tumor necrosis factor (TNF)-antagonist drug. The study, led by researchers at Hospital for Special Surgery in collaboration with rheumatologists at University of Southern California, appears in the February issue of the journal Arthritis & Rheumatism... (Source: Health News from Medical News Today)
Most Patients Gain Weight After Getting A New Knee
You'd think folks who've had knee replacement surgery -- finally able to walk and exercise without pain -- would lose weight instead of put on pounds, but surprisingly that's not the case, according to a University of Delaware study. Researchers Joseph Zeni and Lynn Snyder-Mackler in the Department of Physical Therapy in UD's College of Health Sciences found that patients typically drop weight in the first few weeks after total knee arthroplasty (TKA), but then the number on the scale starts creeping upward, with an average weight gain of 14 pounds in two years... (Source: Health News from Medical News Today)
Most Patients Gain Weight After Getting A New Knee
You'd think folks who've had knee replacement surgery -- finally able to walk and exercise without pain -- would lose weight instead of put on pounds, but surprisingly that's not the case, according to a University of Delaware study... (Source: Rehabilitation News From Medical News Today)
Biomarker Could Help Doctors Tailor Treatment For Rheumatoid Arthritis
Investigators have identified a biomarker that could help doctors select patients with rheumatoid arthritis who will benefit from therapy with drugs such as Enbrel, a tumor necrosis factor (TNF)-antagonist drug... (Source: Arthritis News From Medical News Today)
High-resolution 18F-FDG PET with MRI for monitoring response to treatment in rheumatoid arthritis
Content Type Journal ArticleCategory Image of the MonthDOI 10.1007/s00259-009-1364-xAuthors Abhijit J. Chaudhari, UC Davis Medical Center Department of Radiology Sacramento CA USASpencer L. Bowen, UC Davis Medical Center Department of Radiology Sacramento CA USAGeorge W. Burkett, UC Davis Medical Center Department of Radiology Sacramento CA USANathan J. Packard, UC Davis Medical Center Department of Radiology Sacramento CA USAFelipe Godinez, UC Davis Medical Center Department of Radiology Sacramento CA USAAnand A. Joshi, UCLA School of Medicine Department of Neurology Los Angeles CA USAStanley M. Naguwa, UC Davis Medical Center Department of Internal Medicine Sacramento CA USADavid K. Shelton, UC Davis Medical Center Department of Radiology Sacramento CA USAJohn C. Hunter, UC Davis Med...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Sleep Disturbance, Daytime Sleepiness, and Neurocognitive Performance in Children with Juvenile Idiopathic Arthritis
Conclusion: Indices of sleep disturbance were associated with validated tests of neurobehavioral performance in JIA, regardless of disease activity. Additional research is needed about the extent of sleep disturbances in relation to neurocognitive performance in JIA and compared to healthy children. Keywords: Juvenile idiopathic arthritis, polysomnography, neurobehavioral performance, daytime sleepiness (Source: Sleep)
The genus Mansoa (Bignoniaceae): a source of organosulfur compounds
The genus Mansoa belongs to the family Bignoniaceae and it includes eleven species that occur mainly in the dry and wet forests of Brazil and from Argentina to the Southeast of Mexico. These species in the Brazilian Amazon region are known as "cipó-de-alho", that means garlic vine, in reference to the pungent garlic-like smell of the leaves when crushed. "Cipó-de-alho" has several uses in folk medicine and among them, the most cited are the treatment for cold, fever, pain and inflammation of arthritis and rheumatism. In spite of all those uses, it still has little application in phytotherapy when compared to garlic (Allium sativum). The essential oils of Mansoa spp. show the presence of allyl polysufides that contribute to the characteristic aroma and flavor. The chemical composition of ...
RA Patients Maintain Computer Skills (CME/CE)
The hand impairment experienced by many patients with rheumatoid arthritis did not significantly interfere with their computer use, researchers found. (Source: MedPage Today Geriatrics)
Rheumatoid Arthritis Halted: Researcher Invents Nontoxic Drug That Forces Hyperactive Immune Cells To Die
A researcher from Northwestern University Feinberg School of Medicine has invented a novel way to halt and even reverse rheumatoid arthritis. He developed an imitation of a suicide molecule that floats undetected into overactive immune cells responsible for the disease. Whimsically referred to as Casper the Ghost, the stealthy molecule causes the immune cells to self-destruct. The approach, tested on mice, doesn't carry the health risks of current treatments... (Source: Health News from Medical News Today)
Rheumatoid Arthritis Halted: Researcher Invents Nontoxic Drug That Forces Hyperactive Immune Cells To Die
A researcher from Northwestern University Feinberg School of Medicine has invented a novel way to halt and even reverse rheumatoid arthritis. He developed an imitation of a suicide molecule that floats undetected into overactive immune cells responsible for the disease. Whimsically referred to as Casper the Ghost, the stealthy molecule causes the immune cells to self-destruct... (Source: Immune System / Vaccines News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
BH3 Mimetic May Help Fight RA
A study shows the molecule can infiltrate immune cells to treat rheumatoid arthritis. WebMD Health News (Source: Medscape Today Headlines)
Blood Test May Predict Rheumatoid Arthritis
Proteins in the blood may signal RA years before symptoms develop. WebMD Health News (Source: Medscape Today Headlines)
Blood test may predict rheumatoid arthritis
A simple blood test may allow doctors to identify a debilitating form of arthritis years before any symptoms appear, which may help to stop the disease in its tracks, new research suggests. (Source: CNN.com - Health)
Response: Cricoarytenoid arthritis presenting as croup
(Source: JRSM)
Incidence and risk factors of falling in ambulatory patients with rheumatoid arthritis: a prospective 1-year study
Conclusion&nbsp;&nbsp;We concluded that fall rates in RA patients were higher than in the general population and that balance impairment or side effects of drugs may play a role in increasing the risk of falls. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00198-009-1150-4Authors M. Hayashibara, Tottori University Department of Orthopedic Surgery, Faculty of Medicine Yonago Tottori 683-8504 JapanH. Hagino, Tottori University School of Health Science, Faculty of Medicine Yonago JapanH. Katagiri, Tottori University Hospital Rehabilitation Division Yonago JapanT. Okano, Tottori University Department of Orthopedic Surgery, Faculty of Medicine Yonago Tottori 683-8504 JapanJ. Okada, Tottori University Department of Radiology, Faculty of Medicine Yonago JapanR. Teshi...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice
Abstract&nbsp;&nbsp;ADAM8 is a member of the ?a disintegrin and metalloproteinase? (ADAM) family of membrane-anchored metalloproteinases. ADAM8-deficient mice have no evident spontaneous developmental or pathological defects, and little is currently known about the role of ADAM8 in disease. Here, we investigated the contribution of ADAM8 to pathological neovascularization in mice using an oxygen-induced retinopathy (OIR) model and heterotopical injection of tumor cells. We found an increase in retinal re-vascularization but fewer neovascular tufts in the OIR model and increased growth of heterotopically injected tumor cells in Adam8-/- mice compared with wild-type controls. These results suggest that ADAM8 functions to limit both of these processes in wild-type mice. In cell-based...
Platelet Microparticles Drive Inflammatory Arthritis
Platelets are best known for their critical role in blood clot formation during wound repair, but an appreciation for their role in inflammatory processes is growing. Platelet-derived cellular microparticles (MPs) ? [Read more] (Source: This Week in Science)
[Perspective] Immunology: Arsonists in Rheumatoid Arthritis
Inflammation associated with rheumatoid arthritis is stoked by platelets, expanding their roles into the immune system.Authors: Guy A. Zimmerman, Andrew S. Weyrich (Source: Science: Current Issue)
[Report] Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production
Microparticles released by platelets contribute to inflammation underlying rheumatoid arthritis.Authors: Eric Boilard, Peter A. Nigrovic, Katherine Larabee, Gerald F. M. Watts, Jonathan S. Coblyn, Michael E. Weinblatt, Elena M. Massarotti, Eileen Remold-O?Donnell, Richard W. Farndale, Jerry Ware, David M. Lee (Source: Science: Current Issue)
In this issue
No abstract. (Source: Arthritis and Rheumatism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Adult presentation of Stickler syndrome type III
We describe an adult presentation of the syndrome in a 67-year-old woman and provide a report on the clinical and radiographic features supporting diagnosis. A chart review and updated investigations were performed to elucidate the presenting history and disease progression in the patient. Clinically, the patient was 42&nbsp;years old when she presented with a 22-year history of bilateral knee pain and atypical osteoarthritis (OA) of an inflammatory but non-erosive character. The patient also reported increasing hearing loss for high-pitched frequencies. Radiography/X-rays at age 42&nbsp;years showed severe, non-erosive tri-compartmental OA changes. Atypical destructive changes were identified in the small joints. The son of the patient developed left knee pain and bilateral knee sw...
Shoulder arthrodesis: Description of a modified technique
Summary Objectives&nbsp;&nbsp;Stabilization of the glenohumeral joint to relieve pain and to improve function in instances of muscle paralysis secondary to plexus palsy, destruction of the joint with massive bone loss and large irreparable cuff tears. Indications&nbsp;&nbsp;Paralysis of the rotator cuff or deltoid muscles secondary to brachial plexus lesions or polio. Severe joint degeneration following infection. Massive irreparable cuff tears. Failed arthroplasty. Severe rheumatoid disease. Contraindications&nbsp;&nbsp;Advanced arthritis of the ipsilateral elbow. Arthroplasty of the ipsilateral elbow. Extensive loss of scapulothoracic muscles. Severe thoracic scoliosis and advanced arthritis of the sternoclavicular and acromioclavicular ...
Arthrodesis of proximal interphalangeal joint of toes II to IV using the peg-in-hole technique
Summary Objectives&nbsp;&nbsp;Correction of fixed claw toe deformity of toes II to IV through arthrodesis of the proximal interphalangeal joint and repositioning of metatarsophalangeal joint. Indications&nbsp;&nbsp;Isolated claw toe deformity. Claw toe deformities secondary to rheumatoid arthritis. Contraindications&nbsp;&nbsp;Malalignment of toes after resection arthroplasty associated with marked bone loss. Infected toe. Claw toe deformity of toe V. Surgical Technique&nbsp;&nbsp;Opening of the proximal interphalangeal joint, exposure of the base of the middle phalanx and drilling a hole into the medullary canal. The head of the proximal phalanx is shaped into a peg which is introduced into the hole of the middle phalanx. Temporary stabilization w...
Molecular Therapies for Systemic Lupus Erythematosus: Clinical Trials and Future Prospects
Exploring new pharmacological options and therapeutic avenues for lupus: a focus on non-antibody molecular strategies. Arthritis Research & Therapy (Source: Medscape Today Headlines)
ChemoCentryx Initiates Clinical Trial Of CCX168, A Novel Small Molecule C5aR Antagonist For The Treatment Of Inflammatory And Autoimmune Diseases
ChemoCentryx, Inc., announced the initiation of a Phase I clinical trial of CCX168, an orally-administered small molecule designed to treat autoimmune diseases. CCX168 is a highly potent and very selective compound that specifically targets the C5a receptor (C5aR), a component of the body's complement system and a potent driver of the inflammatory response associated with autoimmune diseases such as systemic lupus erythematosus, certain types of vasculitis, age-related macular degeneration and rheumatoid arthritis... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
$3.75 Million Grant Advances Tissue Engineering Partnership
An award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) will aid a partnership between the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center in finding new ways to use adult stem cells to speed repair of musculoskeletal soft tissue injuries. The five-year grant is for $3.75 million and involves collaboration between UC's Department of Biomedical Engineering and the Division of Developmental Biology at Cincinnati Children's... (Source: Health News from Medical News Today)
$3.75 Million Grant Advances Tissue Engineering Partnership
An award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) will aid a partnership between the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center in finding new ways to use adult stem cells to speed repair of musculoskeletal soft tissue injuries. The five-year grant is for $3... (Source: Bones / Orthopaedics News From Medical News Today)
Rheumatoid Arthritis Doesn't Hinder Computing Skills
A recent study by researchers from the University of Pittsburgh found that workers with rheumatoid arthritis (RA) were comparable to non-impaired individuals in keyboarding speed. Individuals who were trained in touch typing demonstrated faster typing speeds than those using a visually-guided ("hunt and peck") method, regardless of impairment. Researchers also noted slightly impaired mouse skills in workers with RA. Results of this study appear in the February issue of Arthritis Care & Research, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology... (Source: Health News from Medical News Today)
Pediatric Rheumatology: Mortality Rates Significantly Lower Than Previously Reported
A recent study by researchers from the Cleveland Clinic found that the overall mortality rate in the U.S. for all pediatric patients with rheumatic diseases was not worse than the age and sex-adjusted population. Furthermore, mortality rates were significantly lower than reported in previous studies of rheumatic diseases and conditions that are associated with increased mortality. Details of the study appear in the February issue of Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology... (Source: Health News from Medical News Today)

swelling, and heat. Those are symptoms that are typical indications of an injury and they're vital to understanding more about this disease. Second, works by releasing enzymes that basically consume or otherwise destroy the muscles, ligaments, and cartilage that have become inflamed to a point where they're not very useful and don't allow for easy movement. In the worse cases, cartilage disappears completely and as you can guess, this is extremely crippling and uncomfortable.

That's why we call rheumatoid a disease. Typically, inflamed muscles, ligaments, and cartilage are the result of an injury, like falling on the knees for example. But with arthritis, no injury has to occur. In fact, is a type of autoimmune disease and the cartilage inside joints is one of the things that it destroys. And any joint can be affected - one, two, maybe even more but most of the time, the disease targets fingers, hips, feet, and knees.

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George Harper writes for www.arthritisresolved.info where you can find out more about athritis and other topics.