Rheumatoid Arthritis Treatment
By George Harper
I searched a lot online, and certainly you can easily enough find related info, but there is little concerned only with rheumatoid treatment. I hope the following will be interesting to you.

For those suffering from in the spine, palindromic arthritis, viral arthritis, and/or cervical arthritis, coping techniques are simply not the answer. Lumbar arthritis, shoulder arthritis, viral arthritis, and/or psoriasis sufferers, for example, desire permanent pain relief, treatment, new medication, and/or effective drugs.

What is shoulder arthritis, rheumatism, neck arthritis, infectious arthritis, and/or psoriatic pain? Foot pain, back pain, rheumatic pain, knee pain and other pains mean something is wrong in your body. Signs and symptoms of arthritis, signs of arthritis, or pain may begin as morning stiffness. And for millions of us, can become a crippling disease.

Alternative Treatments For Arthritis

Many sufferers have tried unusual and rather nasty ‘cures’ for their disease like enduring bee-stings or covering themselves in cow-manure. The benefits must have been rather less spectacular than the cures or else everyone else would have done the same.

One cure suggests that half a glass of raw potato juice followed by chewing two or three juniper berries will do the trick! While this may be so, many doctors and scientists researching have studied the benefits of taking nutritional substances like vitamins. In fact, studies have shown that people with are mostly deficient in the B group of vitamins, though whether this is due to the disease, or to the fact that taking aspirin depletes the bodies stores of this vitamin is not clear.

Vitamin C, E and beta-carotenes are powerful antioxidants that help to neutralize free radicals. These oxygen-reactive free radical molecules are thought to contribute significantly to disease and tissue damage. It has been found that cells from damaged knee cartilage can release great amounts of free radicals. In fact, studies have shown that those who have a high Vitamin C intake have a two-thirds reduction in the risk of further damage to their knees. Well-known scientist Dr. Linus Pauling recommends 18 grams of V-C per day as an preventative measure.

Osteoarthritis can cause thinning of the bones, and so can prednisone, often given to treat it. It makes sense then to increase the amount of Vitamin D

Statins "could prevent arthritis"
(Source: Nursing in Practice)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Molecular Gatekeeper Of Arthritis Identified
Elimination of a molecular gatekeeper leads to the development of arthritis in mice, scientists report in a study published in The Journal of Experimental Medicine. The newly discovered gatekeeper is a protein that determines the fate - survival or death - of damaging cells that mistakenly attack the body's own tissues and lead to autoimmune disorders such as arthritis. Better understanding how arthritis develops will offer scientists an opportunity to explore new types of treatments for patients whose arthritis has not been effectively treated with current therapies... (Source: Health News from Medical News Today)
The Belgian MIRA (MabThera In Rheumatoid Arthritis) registry: clues for the optimization of rituximab treatment strategies
Conclusions: This study describes the follow-up of a daily clinical practice cohort of 401 RA patients with long-standing refractory disease treated with rituximab. Relatively high DAS28 values at the start of each retreatment, compared to values 6 months after each treatment course, were noted. Moreover, further decrease of DAS28 scores after the second course were more pronounced, especially, in those who didn't show an obvious flare. (Source: BioMed Central)
Long-Term Weight Loss May Be Harmful to Health
Long-term weight loss may release into the blood industrial pollutants linked to illnesses like diabetes, hypertension and rheumatoid arthritis, researchers said on Tuesday. Reuters Health Information (Source: Medscape Diabetes Headlines)
Black Women With SLE Develop Cardiovascular Disease at Early Age
Are black women with SLE more likely to develop heart disease, and, if so, why? Arthritis & Rheumatism Research News Alerts (Source: Medscape Rheumatology Headlines)
Statins reduce arthritis risk
Taking statins, drugs used to lower cholesterol, may reduce the risk of developing rheumatoid arthritis, according to new Israeli research. (Source: Nursing Times Breaking News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
New EULAR Guidelines for Managing Cardiovascular Disease Risk in Rheumatoid Arthritis
Dr. Kevin Deane discusses new recommendations from EULAR for the management of cardiovascular disease in patients with rheumatoid arthritis. Medscape Rheumatology (Source: Medscape Today Headlines)
Molecular gatekeeper of arthritis identified: Removal of key protein leads to initiation of disease
Elimination of a molecular gatekeeper leads to the development of arthritis in mice, scientists report. The newly discovered gatekeeper is a protein that determines the fate -- survival or death -- of damaging cells that mistakenly attack the body's own tissues and lead to autoimmune disorders. Better understanding how arthritis develops will offer scientists an opportunity to explore new treatments for patients who have not had success with current therapies. (Source: ScienceDaily Headlines)
Animal Model Of Rheumatoid Arthritis (KRN-CTM) Deepens Understanding Of The Disease
Current research provides a novel model for rheumatoid arthritis research. The related report by LaBranche et al, "Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse," appears in the September 2010 issue of The American Journal of Pathology. Nearly 1% of the population is affected by rheumatoid arthritis, and women are affected three to five times more often then men... (Source: Health News from Medical News Today)
Solving The Problem Of Cell Death Aids Stem Cell Research
Human pluripotent stem (hPS) cells can generate any given cell type in the adult human body, which is why they are of interest to stem cell scientists working on finding therapies for spinal cord injuries, Parkinson's disease, burns, heart disease, diabetes, arthritis, and other ailments. Before hPS cell technologies can be translated into clinical applications, however, some obstacles must first be overcome... (Source: Health News from Medical News Today)
Cholesterol-Lowering Drugs May Cut RA Risk
Title: Cholesterol-Lowering Drugs May Cut RA RiskCategory: Health NewsCreated: 9/9/2010 10:48:00 AMLast Editorial Review: 9/9/2010 10:48:08 AM (Source: MedicineNet Arthritis General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Elderly May Benefit From Minimally Invasive Shoulder Surgery
Title: Elderly May Benefit From Minimally Invasive Shoulder SurgeryCategory: Health NewsCreated: 9/8/2010 2:10:00 PMLast Editorial Review: 9/9/2010 (Source: MedicineNet Arthritis General)
Statins can cut RA risk
Cholesterol-lowering statin drugs may reduce the risk of developing rheumatoid arthritis, a large study has shown (Source: Pharmacy Europe)
Cholesterol-Lowering Drugs May Cut RA Risk
People who take cholesterol-lowering statin drugs to reduce heart disease risk may also be cutting their risk for developing the painful inflammatory joint disease rheumatoid arthritis. (Source: WebMD Health)
Juvenile arthritis associated with a small increased cancer risk independent of biologic drug use?
Source: Arthritis and Rheumatism Area: News A national cohort study from Sweden shows that patients diagnosed with juvenile idiopathic arthritis (JIA) since 1987 but not treated with biologic drugs have a small, but statistically significant, increase in their risk of cancer compared to controls. &nbsp; Biologic drugs such as the TNF-alpha antagonists have been a major advance in the treatment of arthritis, including that in children (JIA), however there have been adverse event reports linking them with an increased risk of malignancies. This has led to the FDA mandating 'black box' warnings on US prescribing information for these drugs. Determining causality has been hampered, however, by a lack of data on the background rate of cancer in children with JIA although it is known that a...
Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis
Conclusions: B. burgdorferi stimulates PBMC or CD14+ monocytes/macrophages directly to secrete CCL4, but spirochetal stimulation of other intermediate cells, which are present in PBMC, is required to induce CD14+ cells to secrete CCL2, CXCL9 and CXCL10. We conclude that B. burgdorferi stimulates monocytes/macrophages directly and indirectly to guide innate and adaptive immune responses in patients with Lyme arthritis. (Source: Arthritis Research and Therapy)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Statins May Guard Against Rheumatoid Arthritis
Study showed only an association between the two, expert notes (Source: The Doctors Lounge - Cardiology)
Statins May Guard Against Rheumatoid Arthritis
Study showed only an association between the two, expert notes Source: HealthDay Related MedlinePlus Pages: Rheumatoid Arthritis, Statins (Source: MedlinePlus Health News)
Statins linked to lower rheumatoid arthritis risk
LONDON (Reuters) - Israeli scientists have found a significant link between taking cholesterol-lowering statin drugs like Lipitor or Crestor and a reduced risk of developing rheumatoid arthritis. (Source: Reuters: Health)
Cholesterol drug may block arthritis
Conclusion This large cohort study has established a link between longer use of statins and a reduced risk of rheumatoid arthritis and osteoarthritis. It should be noted that the study compared the incidence of rheumatoid arthritis in people taking different amounts of statins, but did not assess arthritis risk in people who did not use statins. Therefore, this study cannot tell us whether taking the drugs is better at preventing rheumatoid arthritis than taking no statins at all. The study?s design had a number of potential limitations: It is not clear whether the study took into account all possible confounding factors (those linked to the exposure and outcome). One important potential confounder is the cholesterol-lowering action of statin drugs. Lower rates of rheumatoid arthrit...
Statin drugs may block arthritis
Conclusion This large cohort study has established a link between longer use of statins and a reduced risk of rheumatoid arthritis and osteoarthritis. It should be noted that the study compared the incidence of rheumatoid arthritis in people taking different amounts of statins, but did not assess arthritis risk in people who did not use statins. Therefore, this study cannot tell us whether taking the drugs is better at preventing rheumatoid arthritis than taking no statins at all. The study?s design had a number of potential limitations: It is not clear whether the study took into account all possible confounding factors (those linked to the exposure and outcome). One important potential confounder is the cholesterol-lowering action of statin drugs. Lower rates of rheumatoid arthri...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Scrotal involvement in an adult with Henoch?Schönlein purpura
We describe a case of acute scrotal swelling as part of a 37-year-old male?s presentation of Henoch?Schönlein purpura, a presentation that has not been reported in this age group. Content Type Journal ArticleDOI 10.1007/s10067-010-1555-7Authors Stephen Aaron, Division of Rheumatology, Department of Internal Medicine, University of Alberta Hospital, 562 Heritage Medical Research Center, Edmonton, Alberta Canada T6G 2S2Lemmese Al-Watban, Department of Family Medicine, University of Alberta, 901 Collage Plaza, Edmonton, Alberta Canada T6G 2C8Donna Manca, Department of Family Medicine, University of Alberta, 901 Collage Plaza, Edmonton, Alberta Canada T6G 2C8 Journal Clinical RheumatologyOnline ISSN 1434-9949Print ISSN 0770-3198 (Source: Clinical Rheumatology)
Weight Loss Raises Industrial Pollutant Levels In Blood
People with long-term weight loss have higher levels of persistent organic pollutants in their blood, which are known to increase the risk of developing rheumatoid arthritis, high blood pressure (hypertension) and diabetes, according to an article published today in the International Journal of Obesity. Persistent organic pollutants (POPs) are organic compounds, they are resistant to environmental degradation - they do not break down easily, so they persist and build up in the environment. POPs can bioaccumulate (build up) in human and animal tissue, as well as food chains... (Source: Health News from Medical News Today)
Central acetabular osteophyte (saber tooth sign), one of the earliest signs of osteoarthritis of the hip joint
We present a radiological sign, the ?Saber tooth? sign, which may be visible on plain radiograph of the hip joint and in computer tomography of the hip joint even prior to the loss of joint space and the onset of hip arthritis. Content Type Journal ArticleDOI 10.1007/s00590-010-0663-zAuthors Ali Mofidi, Wake Forest University Baptist Medical Center, Medical Center Blvd, Winston Salem, NC 27157, USAJohn S. Shields, Wake Forest University Baptist Medical Center, Medical Center Blvd, Winston Salem, NC 27157, USAAllston J. Stubbs, Wake Forest University Baptist Medical Center, Medical Center Blvd, Winston Salem, NC 27157, USA Journal European Journal of Orthopaedic Surgery & TraumatologyOnline ISSN 1432-1068Print ISSN 1633-8065 (Source: European Journal of Orthopaedic Surge...
Associatiion Between Regular Statin Use And A Reduced Risk Of Developing Rheumatoid Arthritis
There is an association between taking statins (lipid lowering drugs), and reduced risk of developing the chronic inflammatory disease, rheumatoid arthritis. These are the findings of a study by Gabriel Chodick and colleagues, published in this week's PLoS Medicine. The researchers conducted a retrospective cohort study among the 1.8-million members of Maccabi Healthcare Services (a health maintenance organization [HMO]) in Israel to identify adults who regularly took statins and did not have rheumatoid arthritis... (Source: Health News from Medical News Today)
Chemical for keeping human pluripotent stem cells alive identified
Researchers have found that a chemically synthesized compound, blebbistatin, can help prevent cell death in human pluripotent stem cells. These cells are of interest to stem cell scientists working on finding therapies for spinal cord injuries, Parkinson's disease, burns, heart disease, diabetes, arthritis, and other ailments. Another advantage of using blebbistatin, say the researchers, is that no human- or animal-derived materials is needed for coating the culture surfaces. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Regular statin use is associated with a reduced risk of developing rheumatoid arthritis
There is an association between taking statins (lipid lowering drugs), and reduced risk of developing the chronic inflammatory disease, rheumatoid arthritis. (Source: ScienceDaily Headlines)
P2.51 The increased expression of B cell activating factor (BAFF) in patients with dermatomyositis
This study was aimed to investigate the role of BAFF in the immunopathogenesis of DM. (Source: Neuromuscular Disorders)
Patients on statins to lower cholesterol 'at less risk of arthritis' study finds
Drugs taken by millions of patients to cut cholesterol levels may also keep arthritis at bay. (Source: the Mail online | Health)
Analysis of C-reactive protein levels and febrile tendency after joint surgery in rheumatoid arthritis patients treated with a perioperative 4-week interruption of tocilizumab
Content Type Journal ArticleDOI 10.1007/s10165-010-0343-1Authors Ryo Hiroshima, Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women?s Medical University, 10-22 Kawada, Shinjuku, Tokyo, 162-0054 JapanKosei Kawakami, Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women?s Medical University, 10-22 Kawada, Shinjuku, Tokyo, 162-0054 JapanTakuji Iwamoto, Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women?s Medical University, 10-22 Kawada, Shinjuku, Tokyo, 162-0054 JapanAsami Tokita, Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women?s Medical University, 10-22 Kawada, Shinjuku, Tokyo, 162-0054 JapanKoichiro Yano, Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women?s Medic...
Risedronic acid: First report of acute arthritis: case report
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Approach to a Child with Monoarthritis
Abstract&nbsp;&nbsp;Arthritis in childhood is common. The pattern, presentation and duration of arthritis help differentiate between the various possible diagnoses. When only one joint is involved, i.e., monoarthritis, it may be difficult to make a diagnosis as there are many possibilities both acute and chronic in nature. A detailed history and clinical examination is important to reach a correct diagnosis and the single most important investigation when a child presents acutely is a joint aspiration to rule out septic arthritis that may destroy the joint in hours. Inflammatory markers, antinuclear antibody testing, test for tuberculosis and imaging (in specific cases) play an important role in the diagnosis of a child that presents with a chronic monoarthritis. In this article we p...
The balance between soluble receptors regulating IL-6 trans-signaling is predictive for the RANKL/osteoprotegerin ratio in postmenopausal women with rheumatoid arthritis
The objective of this study is to investigate the relationship between soluble components of the interleukin 6 (IL-6) system mediating and modifying IL-6 trans-signaling and the RANKL?RANK?osteoprotegerin system in postmenopausal women with rheumatoid arthritis (RA). The following parameters were investigated in 126 postmenopausal women with RA: IL-6, soluble IL-6-receptor (sIL-6R), soluble glycoprotein 130 (sgp130), sRANKL, osteoprotegerin (OPG), osteocalcin, erythrocyte sedimentation rate and C-reactive protein in sera, pyridinolin and desoxypyridinolin crosslinks in the morning urine. Bone mineral density (BMD) was measured by dual X-ray absorptiometry at the lumbar spine (BMD-LS) and at the femoral neck (BMD-FN). Predictors of RANKL/OPG ratio and BMD were evaluated by multipl...
Scientists identify molecular gatekeeper of arthritis
(University of Rochester Medical Center) Elimination of a molecular gatekeeper leads to the development of arthritis in mice, scientists report in the Journal of Experimental Medicine. The newly discovered gatekeeper is a protein that determines the fate -- survival or death -- of damaging cells that mistakenly attack the body's own tissues and lead to autoimmune disorders. Better understanding how arthritis develops will offer scientists an opportunity to explore new treatments for patients who have not had success with current therapies. (Source: EurekAlert! - Medicine and Health)
Statins 'may cut arthritis risk'
Taking statins may reduce the risk of developing rheumatoid arthritis, a study suggests. (Source: BBC News | Health | UK Edition)
Report: Long-Term Weight Loss Could Bring Harmful Health Effects
Long-term weight loss may release into the blood industrial pollutants linked to illnesses like diabetes, hypertension and rheumatoid arthritis, researchers said on Tuesday. These compounds are normally stored in fatty tissues, but when fat breaks down... (Source: OrlandoSentinel: Medical Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Population-based cohort study shows persistence with statins and delays onset of rheumatoid arthritis
Source: PLoS Medicine Area: News According to research published in PLoS Medicine, taking statins may reduce the risk of rheumatoid arthritis (RA). &nbsp; The retrospective cohort study explored whether persistent use of statins is associated with the onset of RA, using a computerised medical database of a large health organisation in Israel, from which diagnosed RA cases among adults who began statin therapy between 1998 and 2007 were evaluated. Persistence with statins was assessed by calculating the mean proportion of follow-up days covered (PDC) with statins for every study participant. To assess the possible effects of healthy user bias, the risk of osteoarthritis (OA), which is unlikely to be affected by use of statins, was also assessed. A total of 211,627 and 193,770 individua...
Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes
Conclusions: The present study reveals not only the effects and mechanisms regarding how resveratrol may protect cartilage from AGEs-mediated damage but also the potential therapeutic benefit of resveratrol in the treatment of OA. (Source: Arthritis Research and Therapy)
J&J Seeks Remicade Damages
Johnson & Johnson is seeking damages from Merck as it negotiates to dissolve a partnership over the big-selling rheumatoid arthritis drug Remicade. (Source: WSJ.com: Health)
What Causes Peripheral Neuropathy?
Discussion Peripheral neuropathy is simply a disease of the peripheral nerves. They can be acute (30%) or chronic (about 67%). About 70% of chronic neuropathy in children is hereditary, 20% is indeterminant and 10% is acquired. Peripheral neuropathies are often present with predominantly distal involvement that is bilateral and symmetric. Sensory symptoms can include numbness, dysesthesia or ataxia. Motor symptoms often include weakness. The autonomic nervous system can also be affected with arrhythmias, hypotension, bowel or bladder problems or abnormal sweating. Learning Point The differential diagnosis of peripheral neuropathy includes: Neurologic Abetaliporteinemia Charcot-Marie Tooth Disease Chronic Inflammatory Demyelinating Polyneuropathy Dejerine-Sottas Giant Axonal Neuropathy Gu...
Long-term weight loss may be harmful to health
HONG KONG (Reuters) - Long-term weight loss may release into the blood industrial pollutants linked to illnesses like diabetes, hypertension and rheumatoid arthritis, researchers said on Tuesday. (Source: Reuters: Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Long-Term Weight Loss May Be Harmful to Health
Long-term weight loss may release into the blood industrial pollutants linked to illnesses like diabetes, hypertension and rheumatoid arthritis, researchers said on Tuesday.Source: Reuters Health Related MedlinePlus Pages: Environmental Health, Weight Control (Source: MedlinePlus Health News)
Peroxisome proliferator-activated receptor gamma in osteoarthritis
Abstract&nbsp;&nbsp;Osteoarthritis (OA) is among the most prevalent chronic human health disorders and the most common form of arthritis. It is a leading cause of disability in developed countries. This disease is characterized by cartilage deterioration, synovitis, and remodeling of the subchondral bone. There is not yet a satisfactory treatment to stop or arrest this disease process. Although several candidates for therapeutic approaches have been put forward, recent studies suggest that activation of the transcription factor peroxisome proliferator-activated receptor gamma (PPAR?) is an interesting target for this disease. PPAR? is a ligand-activated transcription factor and member of the nuclear receptor superfamily. Agonists of PPAR? inhibit inflammation and reduce synthesis ...
Insulin-like growth factor binding protein-related protein 1 is expressed in rheumatoid synovium and regulates synovial fibroblast proliferation
In this report, we examined the expression and function of IGFBP-rP1 in rheumatoid arthritis (RA). IGFBP-rP1 expression in synovial tissues was examined by reverse transcription-polymerase chain reaction (RT-PCR), real-time PCR, and immunohistochemical analysis. In vitro, IGFBP-rP1 expression was examined in synovial fibroblasts established from rheumatoid synovium (RASFs) by RT-PCR, Western blot, and immunostaining. The effect of IGFBP-rP1 small interfering RNA (siRNA) on RASF proliferation was assessed by alamarBlue assay. IGFBP-rP1 mRNA was detected by RT-PCR in all synovial tissues from RA and OA patients. In immunohistochemical analysis, IGFBP-rP1 was mainly expressed in synovial cells in the lining layers and endothelial cells in the sublining layers of RA synovium. In vitro, c...
Casing the joint
(American Journal of Pathology) Current research provides a novel model for rheumatoid arthritis research. The related report by LaBranche et al., "Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse," appears in the September 2010 issue of the American Journal of Pathology. (Source: EurekAlert! - Medicine and Health)
Researchers at UC Riverside find solution to cell death problem vexing stem cell research
(University of California - Riverside) Researchers at the University of California, Riverside, have found that a chemically synthesized compound, blebbistatin, can help prevent cell death in human pluripotent stem cells. These cells are of interest to stem cell scientists working on finding therapies for spinal cord injuries, Parkinson's disease, burns, heart disease, diabetes, arthritis, and other ailments. Another advantage of using blebbistatin, say the researchers, is that no human- or animal-derived materials is needed for coating the culture surfaces. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
NIH expands network focused on how genes affect drug responses
(NIH/National Institute of General Medical Sciences) NIH plans to spend $161.3 million over the next five years to expand the nationwide Pharmacogenomics Research Network. Since its launch in 2000, the network has studied how genes affect individual responses to medicines for heart disease, asthma, various cancers, nicotine addiction and other conditions. In addition to these areas, the expanded network will focus on rheumatoid arthritis, bipolar disorder and the use of pharmacogenetics in rural and underserved populations. (Source: EurekAlert! - Medicine and Health)
The effect of infliximab plus methotrexate on the modulation of inflammatory disease markers in juvenile idiopathic arthritis: analyses from a randomized, placebo-controlled trial
Conclusion: Infliximab + MTX attenuated several inflammatory markers in patients with JIA; larger decreases in ICAM-1, MMP-3, and CRP levels were observed in ACR-Pedi-30 responders versus nonresponders.Trial Registration: NCT00036374 (Source: BioMed Central)
Persistence with Statins and Onset of Rheumatoid Arthritis: A Population-Based Cohort Study
In a retrospective cohort study, Gabriel Chodick and colleagues find a significant association between persistence with statin therapy and reduced risk of developing rheumatoid arthritis, but only a modest decrease in risk of osteoarthritis. (Source: PLoS Medicine)
Topical Gel Catches Up With Pills for Relief
Controlled trials suggest that a topical nonsteroidal anti-inflammatory drug in a cream is as effective as their oral counterparts for treating osteoarthritis, soreness and tendinitis. (Source: NYT Health)
Discovering a New Source of Wrist Pain
(Ivanhoe Newswire) -- Millions of people are diagnosed with carpal tunnel syndrome and arthritis every year. (Source: Medical Headlines From Ivanhoe.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
RESEARCH: Effects of Long?Term Disease?Modifying Antirheumatic Drugs on Endothelial Function in Patients with Early Rheumatoid Arthritis
Rheumatoid arthritis (RA) is associated with enhanced atherosclerosis and impaired endothelial function early after the onset of the disease and cardiovascular (CV) disease represents one of the leading causes of morbidity and mortality. It is well known that disease modifying antirheumatic drugs (DMARDs) are able to improve the course of the disease and the quality of life of these patients, but little is known about the effects of DMARDs on CV risk and endothelial dysfunction. Our goal was to examine the effects of long?term therapy with DMARDs on endothelial function and disease activity in early RA (ERA). Twenty?five ERA patients (mean age 52 ± 14.6 years, disease duration 6.24 ± 4.10 months) without evidence of CV involvement were evaluated for disease activity score (DAS?28),...
Low IgG Poses Infection Risk With Rituximab (CME/CE)
(MedPage Today) -- Certain subgroups of patients with rheumatoid arthritis, particularly those who have low levels of IgG, are at risk for severe infections when treated with rituximab, French investigators found. (Source: MedPage Today Geriatrics)
Acupuncture Not Superior to Sham Acupuncture in Knee Osteoarthritis
Does acupuncture work for patients with knee osteoarthritis? Arthritis Care Research News Alerts (Source: Medscape Orthopaedics Headlines)
Beneficial Effect of Eucommia Polysaccharides on Systemic Lupus Erythematosus-like Syndrome Induced by Campylobacter jejuni in BALB/c Mice
This study was to determine whether the crude polysaccharides (EUPs) isolated from the stem bark of E. ulmoides had beneficial effects on lupus-like syndrome in mice. BALB/c mice were immunized with CJ-S131 in Freund?s complete adjuvant on day&nbsp;0, and then boosted on day&nbsp;14. EUPs 15 or 30&nbsp;mg?kg?1·day?1, or prednisone 5&nbsp;mg?kg?1·day?1 was given to BALB/c mice intragastrically from day&nbsp;0 to 34. Treatment with EUPs 15 or 30&nbsp;mg?kg?1·day?1 for 35&nbsp;days protected kidney from glomerular injury with reduced immunoglobulin deposition and lowered proteinuria. The increased production of serum autoantibodies and total immunoglobulin G (IgG) was also inhibited. These findings suggested that Eucommia polysaccharides had a beneficial effect on syst...
Fatty acids 'may prevent diabetes'
The secret of how fish oil helps prevent heart disease and diabetes is believed to have been unlocked by scientists who now hope to develop new dietary remedies and drugs to reduce conditions such as type-2 diabetes, heart disease and arthritis. (Source: Nursing Times Breaking News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury
The alternative pathway (AP) of complement activation is constitutively active and must be regulated by host proteins to prevent autologous tissue injury. Dysfunction of AP regulatory proteins has been linked to several human inflammatory disorders. Properdin is a positive regulator of AP complement activation that has been shown to extend the half-life of cell surface&#x02013;bound C3 convertase C3bBb; it may also initiate AP complement activation. Here, we demonstrate a critical role for properdin in autologous tissue injury mediated by AP complement activation. We identified myeloid lineage cells as the principal source of plasma properdin by generating mice with global and tissue-specific knockout of Cfp (which encodes properdin) and by generating BM chimeric mice. Properdin deficiency...
Ancient 'Paleo' diet key to healthy living and weight loss, some say
(NaturalNews) Eat like a cave man to lose weight, build muscle and feel great. This is what advocates of the "Paleo" diet say is the key to healthy living, a diet that consists only of meat, vegetables, fruits, nuts, seeds and mushrooms -- also known as the "Paleolithic", or Paleo diet.A recent Chicago Tribune article tells the story of Rick Larson, co-owner of a West Sacramento, Calif., gym called CrossFit. Larson, a Paleo diet supporter, explains in the story that many of his gym members were getting great workouts, but that few were following healthy diets. After experiencing incredible success himself on the Paleo diet, he decided to offer the program to his members as well."For the first time in my life, I started to feel quite healthy. I didn't get any respiratory problems, my arthri...
Osteoporosis Drugs May Be Linked to Cancer Risk
Title: Osteoporosis Drugs May Be Linked to Cancer RiskCategory: Health NewsCreated: 9/3/2010 8:58:00 AMLast Editorial Review: 9/3/2010 8:58:19 AM (Source: MedicineNet Arthritis General)
Loeys-Dietz Syndrome
Title: Loeys-Dietz SyndromeCategory: Diseases and ConditionsCreated: 9/7/2006Last Editorial Review: 9/3/2010 (Source: MedicineNet Arthritis General)
Hope for Arthritis Patients in Fat Tissue
A recent discovery at the UA College of Medicine ? that adult stem cells collected from fat tissue can be converted to cells that will grow cartilage tissue ? has focused one Arizona Arthritis Center lab&#39;s research, promising new hope for osteoarthritis sufferers. (Source: Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Hydrocortisone/methotrexate/prednisone: Septic arthritis in an elderly patient: case report
(Source: Reactions)
The Big Egg Recall: Who is watching the U.S. hens?
Since May 2010, a higher than usual incidence of salmonellosis was reported in several parts of the US that covered 10 states. Salmonellosis is a potentially life-threatening foodborne illness caused by the bacterium Salmonella. Salmonella infection manifests as gastroenteritis, food poisoning or typhoid fever. Symptoms, which take up to 72 hours to appear, include vomiting, diarrhea, fever and abdominal cramps1. Even after recovering from salmonellosis, those infected may still suffer from recurring joint pain and reactive arthritis. (Source: Health WorldNet)
The Big Egg Recall: Who is Watching the Hens?
Since May 2010, a higher than usual incidence of salmonellosis was reported in several parts of the US that covered 10 states. Salmonellosis is a potentially life-threatening foodborne illness caused by the bacterium Salmonella. Salmonella infection manifests as gastroenteritis, food poisoning or typhoid fever. Symptoms, which take up to 72 hours to appear, include vomiting, diarrhea, fever and abdominal cramps.[1] Even after recovering from salmonellosis, those infected may still suffer from recurring joint pain and reactive arthritis. (Source: Health WorldNet)
What is the Evidence for Total Knee Arthroplasty in Young Patients?: A Systematic Review of the Literature.
CONCLUSIONS: TKA provides surgeon-measured clinical and functional improvements with a moderate increase in second-decade implant failures. Improvements in study design and reporting will be beneficial to guide decisions regarding implant selection and surgical technique. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence. PMID: 20814772 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Avesthagen gets 'process' patent for arthritis drug
Bangalore-based drugmaker Avesthagen has got the Indian patent for the process to make a biosimilar drug of Amgen's blockbuster medicine Enbrel. (Source: The Economic Times Healthcare and Biotech News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Avesthagen gets 'process' patent for arthritis drug
Bangalore-based drugmaker Avesthagen has got the Indian patent for the process to make a biosimilar drug of Amgen's blockbuster medicine Enbrel. (Source: The Economic Times Healthcare and Biotech News)
Achieving Drug-free Remission: Elucidating the Role of TNF in Rheumatoid Arthritis
Read this study to learn about the increasing role of biologic therapies in the treatment of rheumatoid arthritis. International Journal of Clinical Rheumatology (Source: Medscape Rheumatology Headlines)
Efficacy and Safety of Various Repeat Treatment Dosing Regimens of Rituximab in Patients With Active Rheumatoid Arthritis: Results of a Phase III Randomized Study (MIRROR)
What is the most effective dosing method of rituximab in patients with active rheumatoid arthritis? Rheumatology (Source: Medscape Rheumatology Headlines)
Arthritis may block Alzheimer's
A protein produced in arthritis may ?protect against the development of Alzheimer's disease,? reported BBC News. US research on mice has discovered that a protein called GM-CSF, produced in rheumatoid arthritis, may trigger the immune system to destroy the protein plaques found in Alzheimer?s disease. (Source: Neurological Conditions Specialist Library)
Behind the headlines - arthritis may block Alzheimer's
A protein produced in arthritis may ?protect against the development of Alzheimer's disease,? reported BBC News. US research on mice has discovered that a protein called GM-CSF, produced in rheumatoid arthritis, may trigger the immune system to destroy the protein plaques found in Alzheimer?s disease. (Source: Neurological Conditions Specialist Library)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Long-term ocular complications in aphakic versus pseudophakic eyes of children with juvenile idiopathic arthritis-associated uveitis
Conclusion With maximum control of perioperative inflammation and intensive follow-up, the implantation of an intraocular lens in well-selected eyes of children with JIA-associated uveitis is not associated with an increased risk of ocular hypertension, secondary glaucoma, cystoid macular oedema and optic disc swelling and showed better visual results up to and including 7&nbsp;years after cataract extraction. (Source: British Journal of Ophthalmology)
DNA From National Psoriasis Victor Henschel BioBank Released For Study
Millions of Americans struggling with psoriasis and psoriatic arthritis are one step closer to a cure with the first-ever release of National Psoriasis Victor Henschel BioBank DNA samples for use in psoriasis research. The samples will allow scientists to uncover the unknowns about the genetics of psoriatic disease and its causes. James T. Elder, M.D., Ph.D... (Source: Health News from Medical News Today)
Original Article: Rheumatoid arthritis and birth outcomes: a Danish and Swedish nationwide prevalence study
Abstract.? (Source: Journal of Internal Medicine)
Editorial Comment: Rheumatoid arthritis and pregnancy: where do we go from here?
(Source: Journal of Internal Medicine)
Overactive Blood Platelets May Play Role in Lupus
Title: Overactive Blood Platelets May Play Role in LupusCategory: Health NewsCreated: 9/1/2010 4:10:00 PMLast Editorial Review: 9/2/2010 (Source: MedicineNet Arthritis General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Case Study Reveals 'Percussionist Wrist' Injury
Title: Case Study Reveals 'Percussionist Wrist' InjuryCategory: Health NewsCreated: 9/1/2010 6:10:00 PMLast Editorial Review: 9/2/2010 (Source: MedicineNet Arthritis General)
Ketoprofen pharmacokinetics, efficacy, and tolerability in pediatric patients.
In conclusion, ketoprofen is effective and well tolerated in children for the control of post-surgical pain and for the control of pain and fever in inflammatory conditions. PMID: 20799760 [PubMed - in process] (Source: Paediatric Drugs)
Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
The objective was to examine the association of baseline demographic and clinical characteristics with sequentially obtained measurements of forced vital capacity (FVC, expressed as a percentage of the predicted value) and to identify predictors of decline rate in FVC over time in the Genetics versus Environment in Scleroderma Outcome Study (GENISOS). Methods: To date, 266 patients were enrolled in GENISOS, a prospective, observational cohort of patients with early systemic sclerosis. In addition to pulmonary function tests (PFT), clinical and laboratory data were obtained from each patient. We analyzed 926 FVC measurements utilizing generalized linear mixed models. The predictive significance of baseline variables for the decline rate in FVC was investigated by the interaction term betwee...
Impact of Prevalent Fractures on Quality of Life: Baseline Results From the Global Longitudinal Study of Osteoporosis in Women
CONCLUSION: Previous fractures at a variety of bone locations, particularly spine, hip, and upper leg, or involving more than 1 location are associated with significant reductions in quality of life. (Source: Mayo Clinic Proceedings)
Mainstream media now citing ridiculous junk science to discredit omega-3s
(NaturalNews) A study out of the Netherlands has put the mainstream media in a mindless tizzy about the health effects of omega-3 fatty acids. Because a group of people fed four teaspoons of omega-3-enriched margarine a day for more than three years did not experience a reduction in heart events, many media outlets are foolishly reporting that omega-3s are not as beneficial as commonly believed.Margarine, as many people now know, is a synthetic, hydrogenated food product that is actually not a food at all. It is a product composed of synthetic trans-fatty acids that are highly toxic and harmful to health. Margarine is exactly the type of substance that causes heart attacks and cardiovascular illness, making it ridiculous to include as part of a health study."[T]rans-fatty acids not only in...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Foot Pain
Title: Foot PainCategory: Diseases and ConditionsCreated: 5/13/2008Last Editorial Review: 9/1/2010 (Source: MedicineNet Arthritis General)
Behind the headlines - Genetic effects of vitamin D studied
?Stocking up on vitamin D supplements and enjoying the summer sun could cut the risk of a host of diseases,? reported the Daily Mail. This news story is based on a study that investigated how vitamin D might influence the risk of certain diseases by affecting the activity of genes. It found that vitamin D binds directly to genes associated with several common autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis and colorectal cancer. Studies of this kind add to our knowledge of the function of vitamin D, and will be used to assess the guidelines for recommended vitamin D intake. What does NHS Choices make of this study? This is a valuable addition to our knowledge of the effects of vitamin D in the cells and how it might affect our risk of certain di...
Behind the headlines - Genetic effects of vitamin D studied
?Stocking up on vitamin D supplements and enjoying the summer sun could cut the risk of a host of diseases,? reported the Daily Mail. This news story is based on a study that investigated how vitamin D might influence the risk of certain diseases by affecting the activity of genes. It found that vitamin D binds directly to genes associated with several common autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis and colorectal cancer. Studies of this kind add to our knowledge of the function of vitamin D, and will be used to assess the guidelines for recommended vitamin D intake. What does NHS Choices make of this study? This is a valuable addition to our knowledge of the effects of vitamin D in the cells and how it might affect our risk of certain di...
Behind the headlines - Genetic effects of vitamin D studied
?Stocking up on vitamin D supplements and enjoying the summer sun could cut the risk of a host of diseases,? reported the Daily Mail. This news story is based on a study that investigated how vitamin D might influence the risk of certain diseases by affecting the activity of genes. It found that vitamin D binds directly to genes associated with several common autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis and colorectal cancer. Studies of this kind add to our knowledge of the function of vitamin D, and will be used to assess the guidelines for recommended vitamin D intake. What does NHS Choices make of this study? This is a valuable addition to our knowledge of the effects of vitamin D in the cells and how it might affect our risk of certain di...
U-M researchers receive largest single collection of psoriasis DNA samples
(University of Michigan Health System) Millions of Americans struggling with psoriasis and psoriatic arthritis are one step closer to a cure with the release of the first National Psoriasis Victor Henschel BioBank DNA samples for use in research at the University of Michigan Health System; research that hopes to uncover the unknowns about the genetics of psoriasis and psoriatic arthritis. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Heterogeneity in juvenile idiopathic arthritis: Impact of molecular profiling based on DNA polymorphism and gene expression patterns
(Source: Arthritis and Rheumatism)
?Muscles ? and bones?
(Source: Arthritis and Rheumatism)
Mast cells and type I interferon responses in the skin of patients with juvenile dermatomyositis: Are current therapies just scratching the surface?
(Source: Arthritis and Rheumatism)
Edward D. Harris, Jr., MD, 1937?2010
(Source: Arthritis and Rheumatism)
Risk factors for severe infections in patients with rheumatoid arthritis treated with rituximab in the autoimmunity and rituximab registry
Abstract (Source: Arthritis and Rheumatism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Anti?apolipoprotein A?1 IgG predicts major cardiovascular events in patients with rheumatoid arthritis
Abstract (Source: Arthritis and Rheumatism)
Glucocorticoid?induced leucine zipper is an endogenous antiinflammatory mediator in arthritis
Abstract (Source: Arthritis and Rheumatism)
Increased friction coefficient and superficial zone protein expression in patients with advanced osteoarthritis
Abstract (Source: Arthritis and Rheumatism)
Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes
Abstract (Source: Arthritis and Rheumatism)
Human articular chondrocytes secrete parathyroid hormone?related protein and inhibit hypertrophy of mesenchymal stem cells in coculture during chondrogenesis
Abstract (Source: Arthritis and Rheumatism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Hypoxia?inducible factor regulation of ANK expression in nucleus pulposus cells: Possible implications in controlling dystrophic mineralization in the intervertebral disc
Abstract (Source: Arthritis and Rheumatism)
Blockade of the interleukin?7 receptor inhibits collagen?induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators
Abstract (Source: Arthritis and Rheumatism)
In vivo microfocal computed tomography and micro?magnetic resonance imaging evaluation of antiresorptive and antiinflammatory drugs as preventive treatments of osteoarthritis in the rat
Abstract (Source: Arthritis and Rheumatism)
Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice
Abstract (Source: Arthritis and Rheumatism)
A novel autoantibody recognizing 200?kd and 100?kd proteins is associated with an immune?mediated necrotizing myopathy
Abstract (Source: Arthritis and Rheumatism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Racial disparities in age at time of cardiovascular events and cardiovascular?related death in patients with systemic lupus erythematosus
Abstract (Source: Arthritis and Rheumatism)
Interferon???dependent inhibition of B cell activation by bone marrow?derived mesenchymal stem cells in a murine model of systemic lupus erythematosus
Abstract (Source: Arthritis and Rheumatism)
Long?term remission after cessation of interferon?? treatment in patients with severe uveitis due to Behçet's disease
Abstract (Source: Arthritis and Rheumatism)
Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells
Abstract (Source: Arthritis and Rheumatism)
Association of subclinical atherosclerosis and leukopenia in systemic autoimmune diseases: Comment on the article by Huang et al
(Source: Arthritis and Rheumatism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Reply
(Source: Arthritis and Rheumatism)
Reply
(Source: Arthritis and Rheumatism)
Lymphoid aggregation is not lymphoid neogenesis: Comment on the article by Klaasen et al
(Source: Arthritis and Rheumatism)
Comparison between adalimumab, etanercept, and infliximab in rheumatoid arthritis: Comment on the article by Hetland et al
(Source: Arthritis and Rheumatism)
Reply
(Source: Arthritis and Rheumatism)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Imaging artifact explains apparent metacarpophalangeal joint erosions in healthy individuals: Comment on the article by Stach et al
(Source: Arthritis and Rheumatism)
Reply
(Source: Arthritis and Rheumatism)
Osteoarthritis, a basic calcium phosphate crystal?associated arthropathy? Comment on the article by Fuerst et al
(Source: Arthritis and Rheumatism)
National Psoriasis Foundation Discovery Research Grant
The National Psoriasis Foundation is seeking grant applications that encourage the advancement of innovative research in psoriasis and psoriatic arthritis. Discovery Research Grants are intended to allow researchers to undertake preliminary and proof of concept studies with the goal of developing competitive grant proposals that lead to long-term funding from the National Institutes of Health or other federal agencies. Research pathways: The National Psoriasis Foundation supports basic and clinical research that leads to the prevention, diagnosis and cure of psoriasis and psoriatic arthritis. Priority consideration will be given to applications that address one or more of the Foundation&rsquo;s research pathways: (1) genetics, (2) cell biology, (3) immunology, and (4) epidemiological...
National Psoriasis Foundation Translational Research Grant
The National Psoriasis Foundation is seeking grant applications that focus on the rapid translation of scientific discoveries arising from laboratory, clinical or population-based studies into clinical applications that have a clear benefit for patients with psoriasis and/or psoriatic arthritis. Research pathways: Priority consideration will be given to applications that address one or more of the Foundation&#39;s research pathways: (1) genetics, (2) cell biology, (3) immunology, and (4) epidemiological/health services research. Anticipated number of awards: It is anticipated that as many as four new Translational Research Grants will be awarded in 2011. Awards are contingent on the availability of funds and the receipt of sufficiently meritorious applications. Budget and Projec...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Increased muscle interstitial levels of inflammatory cytokines in polymyalgia rheumatica
(Source: Arthritis and Rheumatism)
Motion Deficit of the Thumb in CMC Joint Arthritis
Conclusions: Severe stages of thumb CMC OA cause an asymmetrical motion deficit with decreased ROM in extension and adduction, leading to decreased capability of counteropposition. (Source: The Journal of Hand Surgery)
ORIGINAL ARTICLE: Long?term study of infliximab in Japanese patients with plaque psoriasis, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma
(Source: The Journal of Dermatology)
Ultrasound in American Rheumatology Practice: Report of the American College of Rheumatology Musculoskeletal Ultrasound Task Force
(Source: Arthritis Care and Research)
Varus?valgus laxity and passive stiffness in medial knee osteoarthritis
Abstract (Source: Arthritis Care and Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Thigh muscle strength, functional capacity, and self?reported function in patients at high risk of knee osteoarthritis compared with controls
Abstract (Source: Arthritis Care and Research)
Life strain?related tiredness and illness?related fatigue in individuals with ankylosing spondylitis
Abstract (Source: Arthritis Care and Research)
Serum uric acid and risk of occupational disability: Findings from a cohort study of male construction workers in Germany
Abstract (Source: Arthritis Care and Research)
Musculoskeletal pain and incident disability in community?dwelling older adults
Abstract (Source: Arthritis Care and Research)
Risk factors associated with renal lithiasis during uricosuric treatment of hyperuricemia in patients with Gout
Abstract (Source: Arthritis Care and Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Prevalence of cam?type deformity on hip magnetic resonance imaging in young males: A cross?sectional study
Abstract (Source: Arthritis Care and Research)
Rituximab therapy for myopathy associated with anti?signal recognition particle antibodies: A case series
Abstract (Source: Arthritis Care and Research)
Frequency and effectiveness of dose increase of adalimumab, etanercept, and infliximab in daily clinical practice
Abstract (Source: Arthritis Care and Research)
Cross?sectional comparison of extended anteroposterior and posteroanterior fixed flexion positioning to assess radiographic osteoarthritis at the knee: The Johnston County Osteoarthritis Project
Abstract (Source: Arthritis Care and Research)
A 39?year?old woman with Lupus, Myositis, and a Recalcitrant Vasculopathy
(Source: Arthritis Care and Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Does the intraclass correlation coefficient always reliably express reliability? Comment on the article by Cheung et al
(Source: Arthritis Care and Research)
Reply
(Source: Arthritis Care and Research)
ARHP announcements
(Source: Arthritis Care and Research)
T?cell expression of CD91 ? a marker of unresponsiveness to anti?TNF therapy in rheumatoid arthritis
(Source: APMIS)
Adherence, Discontinuation, and Switching of Biologic Therapies in Medicaid Enrollees with Rheumatoid Arthritis
ABSTRACT (Source: Value in Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
A Case of Multicentric Castleman's Disease Having Lung Lesion Successfully Treated with Humanized Anti-interleukin-6 Receptor Antibody, Tocilizumab.
This report presents the case of a patient demonstrating multicentric Castleman's disease (MCD) with a lung lesion that was successfully treated with an anti-interleukin-6 receptor antibody, tocilizumab in combination with corticosteroid and tacrolimus. A 43-yr-old female with abnormal shadows on a chest X-ray was referred to the hospital for further examination. She was diagnosed as having MCD based on the characteristic pathology of inguinal lymph node, lung lesions, laboratory data, and undifferentiated arthritis. Corticosteroid and rituximab therapy did not fully ameliorate the symptoms; thus, the therapeutic regimen was changed to include tocilizumab, oral corticosteroid and tacrolimus. This regimen resulted in clinical remission and the dose of tocilizumab and corticosteroid could be...
Discontinuation of etanercept after successful treatment in patients with juvenile idiopathic arthritis.
Authors: Remesal A, DE Inocencio J, Merino R, Garcia-Consuegra J PMID: 20810527 [PubMed - in process] (Source: J Rheumatol)
Anticyclic citrullinated Peptide antibodies as markers of erosive arthritis in antisynthetase syndrome.
Authors: Cavagna L, Fusetti C, Montecucco C, Caporali R PMID: 20810525 [PubMed - in process] (Source: J Rheumatol)
Work-associated Arthritis Productivity Loss: Where Do We Stand in Its Measurement?
Authors: Burton WN, Schultz A, Chin CY, Edington DW PMID: 20810519 [PubMed - in process] (Source: J Rheumatol)
Early Predictors of Juvenile Sacroiliitis in Enthesitis-related Arthritis.
CONCLUSION: In our cohort, roughly 30% of children with ERA/juvenile idiopathic arthritis develop clinical and MRI evidence of sacroiliitis, detectable with dynamic MRI as early as 1 year after disease onset. Additional data from larger case series are needed to assess the specificity and sensitivity of this technique in the early phase of the disease and to confirm the rate of SI involvement reported in this cohort. PMID: 20810515 [PubMed - as supplied by publisher] (Source: J Rheumatol)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Evaluation of Selected Rheumatoid Arthritis Activity Scores for Office-based Assessment.
CONCLUSION: In RA, the CDAI and RAPID correlated well with the DAS28-CRP4. They may both be practical and informative in the care of patients in the office setting. PMID: 20810513 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Ultrasonographic Measurements of Joint Cartilage Thickness in Healthy Children: Age- and Sex-Related Standard Reference Values.
CONCLUSION: Using US, we established age- and sex-related normal reference intervals for cartilage thickness of the knee, ankle, wrist, and MCP and PIP joints in 7- to 16-year-old children, and designed a formula for calculating hyaline cartilage thickness in all age groups throughout childhood. PMID: 20810511 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Elevated Serum Glucose-6-Phosphate Isomerase Correlates with Histological Disease Activity and Clinical Improvement After Initiation of Therapy in Patients with Rheumatoid Arthritis.
CONCLUSION: Elevated serum GPI may be involved in the synovitis of RA and may prove useful as a serum marker for disease activity of RA. PMID: 20810510 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Pharmacologic Immunomodulation and Cutaneous Malignancy in Rheumatoid Arthritis, Psoriasis, and Psoriatic Arthritis (Review).
CONCLUSION: RA may potentiate the risk of cutaneous malignancy and therefore dermatologic screening in this population should be considered. The use of immunomodulatory therapy in RA, psoriasis, and PsA may further increase the risk of cutaneous malignancy and therefore dermatologic screening examinations are warranted in these groups. More careful recording of skin cancer development during clinical trials and cohort studies is necessary to further delineate the risks of immunomodulatory therapy. PMID: 20810498 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Psoriasis link
About 2% of the general population suffers from psoriasis, a chronic inflammatory disease that affects multiple systems but principally manifests in the skin and joints. Factors that modify this autoimmune disease include genetics, environment, trauma, drugs, sunlight, metabolic factors, psychogenic influences, alcohol, and smoking. Physical conditions associated with psoriasis are cardiovascular disease, metabolic syndrome, inflammatory bowel disease, rheumatoid arthritis, seronegative spondyloarthropathies, malignancy, streptococcal tonsillitis, smoking, alcohol abuse, psychiatric disorders, and stress. Additionally, streptococcal infections can precipitate psoriasis. In chronic destructive periodontal disease, the periodontal supporting tissues are destroyed in an immunologically motiva...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Type 1 diabetes associated with Hashimoto's thyroiditis and juvenile rheumatoid arthritis: a case report with clinical and genetic investigations
Nagy KH, Lukacs K, Sipos P, Hermann R, Madacsy L, Soltesz G. Type 1 diabetes associated with Hashimoto's thyroiditis and juvenile rheumatoid arthritis: a case report with clinical and genetic investigations. (Source: Pediatric Diabetes)
FGF?2 and PDGF, but not Platelet Lysate (PL), induce proliferation dependent, functional MHC?classII antigen in human mesenchymal stem cells (hMSC)
Abstract (Source: Arthritis and Rheumatism)
Atherosclerosis in systemic lupus : The role of antiphospholipid antibodies needs strict diagnostic criteria to be evaluated
(Source: Arthritis Care and Research)
Plasma gelsolin modulates cellular response to sphingosine 1-phosphate.
Authors: Bucki R, Kulakowska A, Byfield FJ, Zendzian-Piotrowska M, Baranowski M, Marzec M, Winer JP, Ciccarelli NJ, Gorski J, Drozdowski W, Bittman R, Janmey PA Hypogelsolinemia is observed in patients with different states of acute or chronic inflammation such as sepsis, rheumatoid arthritis, and multiple sclerosis. In animal models of sepsis, repletion of plasma gelsolin reduces septic mortality. However, the functions of extracellular gelsolin and the mechanisms leading to its protective nature are poorly understood. Potential mechanisms involve gelsolin's extracellular actin scavenging function or its ability to bind bioactive lipids or pro-inflammatory mediators, which would limit inflammatory responses and prevent tissue damage. Here we report that human plasma gelsolin binds to ...

and calcium, both of which are bone-builders. As far back as 1974, British scientists found that lack of vitamin D contributed to bone fractures in the elderly with arthritis. Lack of sunlight and an unhealthy diet both contributed to the lack. The recommended daily dose of Vitamin D is 400 IU or 600 IU if for those over the age of 60. A daily dose of 1200 IU is the limit as this vitamin is toxic if too much is taken.

Vitamin E is also an antioxidant, working in a similar way to vitamin C. Studies in Germany have proven that it can help to reduce pain. Good sources of this vitamin can be found in wheat germ, sunflower seed, corn oil, legumes and whole grains.

While some people swear by the cure that their copper bracelet brought, there is no scientific link to copper as being an aid to arthritis. In fact the opposite is true. Those with RA often have higher levels of copper in their blood. Too much copper can make you sick.

Selenium deficiency can cause a particular type of called Kashin-Bek disease, but it is more common where the soil is deficient in selenium, though sufferers of RA have less in their blood than others. Fish, organ meats, whole grains, nuts and beans will provide selenium.

Zinc may help reduce pain, stiffness and swelling. Some trials showed this was true, though others gave conflicting results. Oysters, cheese and tofu are all good sources of zinc.

The pain of can also be relieved by hot-packs, deliberately focussing on something else like pleasant music, humor, gentle exercise and losing weight.

Article Source: http://www.ArticleJoe.com

George Harper writes for www.arthritisresolved.info where you can find out more about athritis and other topics.